The A-Z of Zika drug discovery

dc.creatorMottin, Melina
dc.creatorBorba, Joyce V. V. B.
dc.creatorBraga, Rodolpho C.
dc.creatorTorres, Pedro H. M.
dc.creatorMartini, Matheus C.
dc.creatorMódena, Jose Luiz Proenca
dc.creatorJudice, Carla C.
dc.creatorCosta, Fabio T. M.
dc.creatorEkins, Sean
dc.creatorPerryman, Alexander L.
dc.creatorAndrade, Carolina Horta
dc.date2018-08-02T12:47:52Z
dc.date2018-08-02T12:47:52Z
dc.date2018
dc.date.accessioned2023-09-27T00:14:12Z
dc.date.available2023-09-27T00:14:12Z
dc.identifierMOTTIN, Melina; et al. The A–Z of Zika drug discovery. Drug Discovery Today, v.00, n.00, 15p, June 2018.
dc.identifier1359-6446
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27785
dc.identifier10.1016/j.drudis.2018.06.014
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898813
dc.descriptionDespite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A-Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectZika Virus
dc.subjectMedicamentos
dc.subjectZika Virus
dc.subjectDrugs discovery
dc.titleThe A-Z of Zika drug discovery
dc.typeArticle


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