Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae)

dc.creatorSilva, Carmelita G.
dc.creatorSantos Júnior, Helvécio M.
dc.creatorBarbosa, Jussara P.
dc.creatorCosta, Gisela L.
dc.creatorRodrigues, Felipe A. R.
dc.creatorOliveira, Denilson F.
dc.creatorLotufo, Letícia V. Costa
dc.creatorAlves, Ruy J. V.
dc.creatorEleutherio, Elis C. A.
dc.creatorRezende, Claudia M.
dc.date2016-05-17T12:22:01Z
dc.date2016-05-17T12:22:01Z
dc.date2015
dc.date.accessioned2023-09-27T00:14:11Z
dc.date.available2023-09-27T00:14:11Z
dc.identifierSILVA, Carmelita G. et al. Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae). Chemistry & Biodiversity, v. 12, n. 2, p. 1891-1901, Dec. 2015.
dc.identifier1612-1872
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/14304
dc.identifier10.1002/cbdv.201500071
dc.identifier1612-1880
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898811
dc.descriptionA new halimane diterpene was isolated from Vellozia kolbekii Alves (Velloziaceae) and identified as (5R,8R,9S,13R)-halim-1,10-ene-15,16-diol (1). It showed cytotoxicity against three human cancer cell lines, SF-295 (glioblastoma), MDA-MB-435 (melanoma), and HCT-8 (colon adenocarcinoma). In the mechanism of cytotoxic action, halimane 1 interferes in two major phases of the cell cycle: in S phase, in which DNA synthesis occurs and where it is very sensitive to damage, and G2M phase which is the phase of preparation for mitosis and mitosis itself, showing apoptosis-inducing properties. Antimicrobial activity towards Gram-positive and Gram-negative bacteria was studied and, against Bacillus cereus, B. subtilis, Escherichia coli, and Pseudomonas aeruginosa, a MIC value of 0.025 μM was observed for halimane 1, which is more active than the positive control chloramphenicol.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectCitotoxicidade
dc.subjectAtividade Antimicrobiana
dc.subjectCâncer
dc.subjectVelloziaceae
dc.subjectAntimicrobial activity
dc.subjectCytotoxicity
dc.subjectVellozia kolbekii
dc.subjectCancer
dc.titleStructure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae)
dc.typeArticle


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