Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country

dc.creatorNassar Junior, Antonio Paulo
dc.creatorTrevisani, Mariane da Silva
dc.creatorBettim, Barbara Beltrame
dc.creatorZampieri, Fernando Godinho
dc.creatorCarvalho Jr, José Albani
dc.creatorSilva Jr, Amilton
dc.creatorFreitas, Flávio Geraldo Rezende de
dc.creatorPinto, Jorge Eduardo da Silva Soares
dc.creatorRomano, Edson
dc.creatorRamos, Silvia Regina
dc.creatorFaria, Guilherme Brenande Alves
dc.creatorAndrade-E-Silva, Ulysses V.
dc.creatorSantos, Robson Correa
dc.creatorTommasi, Edmundo de Oliveira
dc.creatorMoraes, Ana Paula Pierre de
dc.creatorCruz, Bruno Azevedo da
dc.creatorBozza, Fernando Augusto
dc.creatorCaruso, Pedro
dc.creatorSalluh, Jorge Ibrahin Figueira
dc.creatorSoares, Marcio
dc.date2020-10-31T18:59:38Z
dc.date2020-10-31T18:59:38Z
dc.date2020
dc.date.accessioned2023-09-27T00:14:09Z
dc.date.available2023-09-27T00:14:09Z
dc.identifierNASSAR JUNIOR, Antonio Paulo et al. Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country. PloS One, v. 15, n. 8, p. 1-10, 2020.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44294
dc.identifier10.1371/journal.pone.0238124
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898803
dc.descriptionBackground: Very elderly critically ill patients (ie, those older than 75 or 80 years) are an increasing population in intensive care units. However, patients with cancer have encompassed only a minority in epidemiological studies of very old critically-ill patients. We aimed to describe clinical characteristics and identify factors associated with hospital mortality in a cohort of patients aged 80 or older with cancer admitted to intensive care units (ICUs). Methods: This was a retrospective cohort study in 94 ICUs in Brazil. We included patients aged 80 years or older with active cancer who had an unplanned admission. We performed a mixed effect logistic regression model to identify variables independently associated with hospital mortality. Results: Of 4604 included patients, 1807 (39.2%) died in hospital. Solid metastatic (OR = 2.46; CI 95%, 2.01-3.00), hematological cancer (OR = 2.32; CI 95%, 1.75-3.09), moderate/severe performance status impairment (OR = 1.59; CI 95%, 1.33-1.90) and use of vasopressors (OR = 4.74; CI 95%, 3.88-5.79), mechanical ventilation (OR = 1.54; CI 95%, 1.25-1.89) and renal replacement (OR = 1.81; CI 95%, 1.29-2.55) therapy were independently associated with increased hospital mortality. Emergency surgical admissions were associated with lower mortality compared to medical admissions (OR = 0.71; CI 95%, 0.52-0.96). Conclusions: Hospital mortality rate in very elderly critically ill patients with cancer with unplanned ICU admissions are lower than expected a priori. Cancer characteristics, performance status impairment and acute organ dysfunctions are associated with increased mortality.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectRenal cancer
dc.subjectIntensive care units
dc.subjectProstate cancer
dc.subjectBreast cancer
dc.subjectGeriatric care
dc.titleElderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country
dc.typeArticle


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