Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

dc.creatorMathad, Jyoti S
dc.creatorGupte, Nikhil
dc.creatorBalagopal, Ashwin
dc.creatorAsmuth, David M
dc.creatorHakim, James
dc.creatorSantos, Breno
dc.creatorRiviere, Cynthia
dc.creatorHosseinipour, Mina
dc.creatorSugandhavesa, Patcharaphan
dc.creatorInfante, Rosa
dc.creatorPillay, Sandy
dc.creatorCardoso, Sandra Wagner
dc.creatorMwelase, Noluthando
dc.creatorPawar, Jyoti
dc.creatorBerendes, Sima
dc.creatorKumarasamy, Nagalingeswaran
dc.creatorAndrade, Bruno de Bezerril
dc.creatorCampbell, Thomas B
dc.creatorCurrier, Judith S
dc.creatorCohn, Susan E
dc.creatorGupta, Amita
dc.date2017-02-16T16:52:16Z
dc.date2017-02-16T16:52:16Z
dc.date2016
dc.date.accessioned2023-09-27T00:14:03Z
dc.date.available2023-09-27T00:14:03Z
dc.identifierMATHAD, Jyoti S. et al. Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation. Journal Acquir. Immune Defic. Syndr., v. 73, p. 123–129, 2016.
dc.identifier1077-9450
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17845
dc.identifier10.1097/QAI.0000000000001095
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898786
dc.descriptionThe authors thank the Prospective Evaluation of Antiretrovirals in Resource-Limited Setting study participants for volunteering their time and efforts.
dc.descriptionUS National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). NIH/NIAID Johns Hopkins Baltimore Washington India HIV Clinical Trials Unit. NIH/National Center for Advancing Translational Sciences. Ujala Foundation. Johns Hopkins Center for AIDS Research and the Gilead Foundation.
dc.descriptionBackground: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon g, tumor necrosis factor (TNF) a, IL-6, IL-18, IFN-g–induced protein 10, C-reactive protein (CRP), lipopolysaccharide, and sCD14] were measured at weeks 0, 24, and 48 after combination antiretroviral therapy (cART) in a random subcohort (n = 215) who achieved virologic suppression in ACTG A5175 (Prospective Evaluation of Antiretrovirals in Resource-Limited Settings). Association between sex and changes in markers postcART was examined using random effects models. Average marker differences and 95% confidence intervals were estimated using multivariable models. Results: At baseline, women had lower median log10 viral load (4.93 vs 5.18 copies per milliliter, P = 0.01), CRP (2.32 vs 4.62 mg/L, P =0.01), detectable lipopolysaccharide (39% vs 55%, P = 0.04), and sCD14 (1.9 vs 2.3 mg/mL, P = 0.06) vs men. By week 48, women had higher interferon g (22.4 vs 14.9 pg/mL, P = 0.05), TNF-a (11.5 vs 9.5pg/mL, P = 0.02), and CD4 (373 vs 323 cells per cubic millimeter, P =0.02). In multivariate analysis, women had greater increases in CD4 and TNF-a but less of a decrease in CRP and sCD14 compared with men. Conclusions: With cART-induced viral suppression, women have less reduction in key markers of inflammation and immune activation compared with men. Future studies should investigate the impact of these sex-specific differences on morbidity and mortality.
dc.description2017-10-02
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsopen access
dc.subjectHIV
dc.subjectInflamação
dc.subjectAtivação imunológica
dc.subjectSexo
dc.subjectMulheres
dc.subjectTratamento antiretroviral
dc.subjectHIV
dc.subjectInflammation
dc.subjectImmune activation
dc.subjectSex
dc.subjectWomen
dc.subjectAntiretroviral treatment
dc.subjectHIV
dc.subjectComportamento Sexual
dc.titleSex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation
dc.typeArticle


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