HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population

dc.creatorAlencar, Liciana Xavier Eurico de
dc.creatorBraga-Neto, Ulisses de Mendonça
dc.creatorNascimento, Eduardo José Moura do
dc.creatorCordeiro, Marli Tenório
dc.creatorSilva, Ana Maria
dc.creatorBrito, Carlos Alexandre Antunes de
dc.creatorSilva, Maria da Paz Carvalho da
dc.creatorGil, Laura Helena Vega Gonzales
dc.creatorMontenegro, Silvia Maria Lucena
dc.creatorMarques, Ernesto Torres de Azevedo
dc.date2017-12-13T12:13:41Z
dc.date2017-12-13T12:13:41Z
dc.date2013
dc.date.accessioned2023-09-27T00:13:54Z
dc.date.available2023-09-27T00:13:54Z
dc.identifierALENCAR, L. Xavier Eurico de et al. HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine, v. 2013, p. 648475, 2013.
dc.identifier1687-9686
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23632
dc.identifier10.1155/2013/648475
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898760
dc.descriptionHuman leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher's association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B∗44 (P = 0.047, OR = 2.025, 95% CI = 0.97-4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B∗07 (P = 0.048, OR = 0.501, one-sided 95% CI = 0-0.99) and HLA-DR∗13 (P = 0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B∗44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B∗07 supertype alleles and DR∗13 might be involved in cross-dengue serotype immunity.
dc.formatapplication/pdf
dc.languageeng
dc.publisherJean-Paul Gonzalez
dc.rightsopen access
dc.subjectDengue
dc.subjectBrasil
dc.subjectepidemiologia
dc.subjectDoenças Endêmicas, prevenção & controle.
dc.subjectDengue
dc.subjectBrazil
dc.subjectepidemiology
dc.subjectEndemic Diseases, prevention & control
dc.subjectestudos transversais
dc.subjectVírus da dengue
dc.subjectDengue
dc.subjectprevenção & controle
dc.subjectInfecção por Vírus da Dengue
dc.subjectHumanos
dc.subjectVírus da Dengue
dc.subjectgenética
dc.subjectVírus da Dengue
dc.subjectvirologia
dc.subjectBrasil
dc.subjectepidemiologia
dc.subjectDengue Grave
dc.subjectcomplicações
dc.subjectVírus da Dengue
dc.subjectclassificação
dc.subjectDNA
dc.subjectFeminino
dc.subjectMasculino
dc.subjectÍndice de Gravidade de Doença
dc.subjectDengue Grave
dc.subjectdiagnóstico
dc.titleHLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population
dc.typeArticle


Este ítem pertenece a la siguiente institución