dc.creatorSouza, Elaine Waite de
dc.creatorBorba, Cintia de Moraes
dc.creatorPereira, Sandro Antonio
dc.creatorGremião, Isabella Dib Ferreira
dc.creatorLangohr, Ingeborg Maria
dc.creatorOliveira, Manoel Marques Evangelista
dc.creatorOliveira, Raquel de Vasconcellos Carvalhaes de
dc.creatorCunha, Camila Rocha de
dc.creatorZancopé-Oliveira, Rosely Maria
dc.creatorMiranda, Luisa Helena Monteiro de
dc.creatorMenezes, Rodrigo Caldas
dc.date2018-07-30T18:13:40Z
dc.date2018-07-30T18:13:40Z
dc.date2018
dc.date.accessioned2023-09-27T00:13:43Z
dc.date.available2023-09-27T00:13:43Z
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27723
dc.identifier10.1038/s41598-018-27447-5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898731
dc.descriptionSOUZA, Elaine Waite de et al. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. Scientific Reports, v. 8, p. 1-10, 2018.
dc.descriptionZoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats coinfected with FIV/FeLV (n = 12) had a lower neutrophil count in the lesion. A high fungal load in skin lesions was linked to young age and treatment failure, as well as to a longer time of wound healing, poorly formed granulomas and fewer neutrophils, macrophages and lymphocytes in these lesions. These results indicate that itraconazole is effective, but nasal mucosal involvement, respiratory signs and high fungal loads in skin lesions are predictors of treatment failure that will assist in the development of better treatment protocols for cats.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCats
dc.subjectSporothrix brasiliensis
dc.subjectSporotrichosis
dc.titleClinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis
dc.typeArticle


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