CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region

dc.creatorSalles, Paula Ferreira
dc.creatorSilva, Daiana Souza Perce da
dc.creatorRossi, Atila Duque
dc.creatorRaposo, Luisa Riehl
dc.creatorRamirez, Aina Danaisa Ramirez
dc.creatorBastos, Otílio Machado Pereira
dc.creatorPratt-Riccio, Lilian Rose
dc.creatorCassiano, Gustavo Capatti
dc.creatorBaptista, Andrea Regina Souza
dc.creatorCardoso, Cynthia Chester
dc.creatorBanic, Dalma Maria
dc.creatorMachado, Ricardo Luiz Dantas
dc.date2022-01-21T14:37:02Z
dc.date2022-01-21T14:37:02Z
dc.date2021
dc.date.accessioned2023-09-27T00:13:36Z
dc.date.available2023-09-27T00:13:36Z
dc.identifierSALLES, Paula Ferreira et al. CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region. Frontiers in Pharmacology, v. 12, Article 542342, p. 1 - 8, July 2021.
dc.identifier1663-9812
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50845
dc.identifier10.3389/fphar.2021.542342
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898709
dc.descriptionGenetic variability was linked with individual responses to treatment and susceptibility to malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The aim of the study was to investigate whether or not CYP2D6 single nucleotide polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally distributed in malaria by Plasmodium vivax individuals from the Brazilian Amazon region. The blood samples were collected from 220 unrelated Plasmodium vivax patients from five different endemic areas. Genotyping was performed using SNaPshot® and real-time polymerase chain reaction methods. In all five areas, the rs1065852 (CYP2D6*10, C.100C > T), rs3892097 (CYP2D6*4, 1846C > T) and rs16947 (CYP2D6*2, C.2850G > A), as a homozygous genotype, showed the lowest frequencies. The rs28371725 (CYP2D6*41, 2988G > A) homozygous genotype was not detected, while the allele A was found in a single patient fromMacapá region. No deviations from Hardy-Weinberg equilibrium were found, although a borderline p-value was observed (p 0.048) for the SNP rs3892097 in Goianésia do Pará, Pará state. No significant associations were detected in these frequencies among the five studied areas. For the SNP rs3892097, a higher frequency was observed for the C/T heterozygous genotype in the Plácido de Castro and Macapá, Acre and Amapá states, respectively. The distribution of the CYP2D6 alleles investigated in the different areas of the Brazilian Amazon is not homogeneous. Further investigations are necessary in order to determine which alleles might be informative to assure optimal drug dosing recommendations based on experimental pharmacogenetics.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectCYP2D6
dc.subjectFarmacogenética
dc.subjectPrimaquina
dc.subjectPlasmodium vivax
dc.subjectPolimorfismo genético
dc.subjectRecaídas
dc.subjectAmazônia brasileira
dc.subjectÁreas endêmicas
dc.subjectPharmacogenetics
dc.subjectCYP2D6
dc.subjectPrimaquine
dc.subjectPlasmodium vivax
dc.subjectGenetic polymorphism
dc.subjectRelapses
dc.subjectBrazilian Amazon region
dc.subjectEndemic Areas
dc.titleCYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region
dc.typeArticle


Este ítem pertenece a la siguiente institución