Lipid bodies in inflammatory cells: structure, function, and current imaging techniques

dc.creatorMelo, Rossana C. N.
dc.creatorD'Avila, Heloisa
dc.creatorWan, Hsiao-Ching
dc.creatorBozza, Patrícia T.
dc.creatorDvorak, Ann M.
dc.creatorWeller, Peter F.
dc.date2017-11-01T16:33:27Z
dc.date2017-11-01T16:33:27Z
dc.date2011
dc.date.accessioned2023-09-27T00:13:14Z
dc.date.available2023-09-27T00:13:14Z
dc.identifierMELO, Rossana C. N. et al. Lipid Bodies in Inflammatory Cells: Structure, Function, and Current Imaging Techniques. Journal of Histochemistry & Cytochemistry v.59, n.5, p.540–556, 2011.
dc.identifier0022-1554
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23031
dc.identifier10.1369/0022155411404073
dc.identifier1551-5044
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898646
dc.descriptionLipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as functionally active organelles linked to diverse biological functions and human diseases. These organelles are actively formed in vivo within cells from the immune system, such as macrophages, neutrophils, and eosinophils, in response to different inflammatory conditions and are sites for synthesis and storage of inflammatory mediators. In this review, the authors discuss structural and functional aspects of LBs and current imaging techniques to visualize these organelles in cells engaged in inflammatory processes, including infectious diseases. The dynamic morphological aspects of LBs in leukocytes as inducible, newly formable organelles, elicitable in response to stimuli that lead to cellular activation, contribute to the evolving understanding of LBs as organelles that are critical regulators of different inflammatory diseases, key markers of leukocyte activation, and attractive targets for novel anti-inflammatory therapies.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSAGE Publications
dc.rightsrestricted access
dc.subjectgota de lípido
dc.subjectLeucócitos
dc.subjectMacrófagos
dc.subjectInflamação
dc.subjectimmune immunity
dc.subjecteicosanóides
dc.subjectmicroscopia eletrônica
dc.subjectmicroscopia de fluorescência
dc.subjecttécnicas de imagem
dc.subjectproteína relacionada à diferenciação adiposa
dc.subjectlipid droplet
dc.subjectleokocytes
dc.subjectmacrophages
dc.subjectinflammation
dc.subjectimmune immunity
dc.subjecteicosanoids
dc.subjectadipose differentiation-related protein
dc.subjectelectron microscopy
dc.subjectfluorescence microscopy
dc.subjectimaging techniques
dc.titleLipid bodies in inflammatory cells: structure, function, and current imaging techniques
dc.typeArticle


Este ítem pertenece a la siguiente institución