Proteomics pinpoints alterations in grade I meningiomas of male versus female patients

dc.creatorSilva, Janaína M.
dc.creatorWippel, Helisa Helena
dc.creatorVerissimo, Denildo C. A.
dc.creatorSantos, Renata M.
dc.creatorNogueira, Fábio C. S.
dc.creatorPassos, Gustavo A. R.
dc.creatorSprengel, Sergio L.
dc.creatorBorba, Luis A. B.
dc.creatorCarvalho, Paulo Costa
dc.creatorFischer, Juliana de Saldanha da Gama
dc.date2020-08-03T22:11:30Z
dc.date2020-08-03T22:11:30Z
dc.date2020
dc.date.accessioned2023-09-27T00:13:12Z
dc.date.available2023-09-27T00:13:12Z
dc.identifierSILVA, Janaina M. et al. Proteomics pinpoints alterations in grade I meningiomas of male versus female patients. Plos One, v. 10, n. 10335, p. 1-11, 2020.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42522
dc.identifier10.1038/s41598-020-67113-3
dc.identifier2045-2322
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898641
dc.descriptionMeningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells of the meninges. Surgery is the first option of treatment, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Reports indicate many differences in meningiomas from male versus female patients; for example, incidence is higher in females, whereas males usually develop the malignant and more aggressive type. With this as motivation, we used shotgun proteomics to compare the proteomic profile of grade I meningioma biopsies of male and female patients. Our results listed several differentially abundant proteins between the two groups; some examples are S100-A4 and proteins involved in RNA splicing events. For males, we identified enriched pathways for cell-matrix organization and for females, pathways related to RNA transporting and processing. We believe our findings contribute to the understanding of the molecular differences between grade I meningiomas of female and male patients.
dc.formatapplication/pdf
dc.languagepor
dc.publisherNature Research
dc.rightsopen access
dc.subjectMeningioma
dc.subjectMolecular Structure
dc.subjectMale
dc.subjectFemale
dc.subjectCentral Nervous System Neoplasms
dc.subjectEstructura Molecular
dc.subjectFemenino
dc.subjectNeoplasias del Sistema Nervioso Central
dc.subjectEstrutura Molecular
dc.subjectMasculino
dc.subjectFeminino
dc.subjectNeoplasias do Sistema Nervoso Central
dc.titleProteomics pinpoints alterations in grade I meningiomas of male versus female patients
dc.typeArticle


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