Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, Is associated with HIV disease progression in resource-constrained settings

dc.creatorShivakoti, Rupak
dc.creatorYang, Wei-Teng
dc.creatorBerendes, Sima
dc.creatorMwelase, Noluthando
dc.creatorKanyama, Cecilia
dc.creatorPillay, Sandy
dc.creatorSamaneka, Wadzanai
dc.creatorSantos, Breno
dc.creatorPoongulali, Selvamuthu
dc.creatorTripathy, Srikanth
dc.creatorRiviere, Cynthia
dc.creatorLama, Javier R.
dc.creatorCardoso, Sandra W.
dc.creatorSugandhavesa, Patcharaphan
dc.creatorBalagopal, Ashwin
dc.creatorGupte, Nikhil
dc.creatorSemba, Richard D.
dc.creatorCampbell, Thomas B.
dc.creatorBollinger, Robert C.
dc.creatorGupta, Amita
dc.creatorNWCS 319 and PEARLS Study Team
dc.date2018-10-08T18:43:49Z
dc.date2018-10-08T18:43:49Z
dc.date2016
dc.date.accessioned2023-09-27T00:13:09Z
dc.date.available2023-09-27T00:13:09Z
dc.identifierSHIVAKOTI, Rupak. et al. Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, Is associated With HIV disease progression in resource-constrained settings. The Journal of Infectious Diseases, v. 213, n. 7, p. 1074–1078, 2016.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29443
dc.identifier10.1093/infdis/jiv573
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898632
dc.descriptionA case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of CRP levels, and their association with HIV clinical failure. A persistently elevated CRP level in plasma (defined as ≥ 5 mg/L at both baseline and 24 weeks after ART initiation) was observed in 50 of 205 individuals (24%). A persistently elevated CRP level but not an elevated CRP level only at a single time point was independently associated with increased clinical failure, compared with a persistently low CRP level, despite achievement of virologic suppression. Serial monitoring of CRP levels could identify individuals who are at highest risk of HIV progression and may benefit from future adjunct antiinflammatory therapies.
dc.description2028-08-30
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectHIV
dc.subjectInflammation
dc.subjectCRP
dc.subjectPersistent inflammation
dc.subjectAntiretroviral therapy
dc.titlePersistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, Is associated with HIV disease progression in resource-constrained settings
dc.typeArticle


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