| dc.creator | Borges, Juliana Pereira | |
| dc.creator | Lessa, Marcos Adriano | |
| dc.date | 2016-04-18T12:45:49Z | |
| dc.date | 2016-04-18T12:45:49Z | |
| dc.date | 2015 | |
| dc.date.accessioned | 2023-09-27T00:13:08Z | |
| dc.date.available | 2023-09-27T00:13:08Z | |
| dc.identifier | BORGES, Juliana Pereira; LESSA, Marcos Adriano. Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review. Arq. Bras Cardiol., v.105, n.1, p.71-81, 2015. | |
| dc.identifier | 0066-782X | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/13841 | |
| dc.identifier | 10.5935/abc.20150024 | |
| dc.identifier | 1678-4170 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8898629 | |
| dc.description | Background: Acute myocardial infarction is the leading cause of morbidity and mortality worldwide. Furthermore, research
has shown that exercise, in addition to reducing cardiovascular risk factors, can also protect the heart against injury due to
ischemia and reperfusion through a direct effect on the myocardium. However, the specific mechanism involved in exerciseinduced
cardiac preconditioning is still under debate.
Objective: To perform a systematic review of the studies that have addressed the mechanisms by which aerobic exercise
promotes direct cardioprotection against ischemia and reperfusion injury.
Methods: A search was conducted using MEDLINE, Literatura Latino-Americana e do Caribe de Informação em Ciências da
Saúde, and Scientific Electronic Library Online databases. Data were extracted in a standardized manner by two independent
researchers, who were responsible for assessing the methodological quality of the studies.
Results: The search retrieved 78 studies; after evaluating the abstracts, 30 studies were excluded. The manuscripts of
the remaining 48 studies were completely read and, of these, 20 were excluded. Finally, 28 studies were included in this
systematic review.
Conclusion: On the basis of the selected studies, the following are potentially involved in the cardioprotective response
to exercise: increased heat shock protein production, nitric oxide pathway involvement, increased cardiac antioxidant
capacity, improvement in ATP-dependent potassium channel function, and opioid system activation. Despite all the
previous investigations, further research is still necessary to obtain more consistent conclusions. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedade Brasileira de Cardiologia - SBC | |
| dc.rights | open access | |
| dc.subject | Myocardial Infarction | |
| dc.subject | Exercise/physiology | |
| dc.subject | Myocardial Reperfusion Injury/etiology | |
| dc.subject | Myocardial Ischemia | |
| dc.subject | Heat-Shock Proteins | |
| dc.subject | Infarto do Miocárdio | |
| dc.subject | Reperfusão Miocárdica | |
| dc.subject | Traumatismo por Reperfusão Miocárdica | |
| dc.subject | Isquemia Miocárdica | |
| dc.subject | Proteínas de Choque Térmico | |
| dc.title | Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review | |
| dc.type | Article | |
