Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity

dc.creatorTeles, Amanda Mara
dc.creatorRosa, Taynan Dulce da Silva
dc.creatorMouchrek, Adenilde Nascimento
dc.creatorSilva, Ana Lucia Abreu
dc.creatorCalabrese, Kátia da Silva
dc.creatorSouza, Fernando Almeida
dc.date2019-05-02T16:03:06Z
dc.date2019-05-02T16:03:06Z
dc.date2019
dc.date.accessioned2023-09-27T00:13:04Z
dc.date.available2023-09-27T00:13:04Z
dc.identifierTELES, Amanda Mara et al. Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 2421965, 12p, 2019.
dc.identifier1741-427X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32916
dc.identifier10.1155/2019/2421695
dc.identifier1741-4288
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898617
dc.descriptionThe resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils. Chemical analysis was performed by gas chromatography-mass spectrometry. Antimicrobial activity was performed by disk diffusion and minimum inhibitory concentration (MIC) test. Antileishmanial activity was performed against antipromastigote and intracellular amastigote of Leishmania amazonensis. Cytotoxic and nitrite production were realized in BALB/c peritoneal macrophages. The major compounds of the essential oils were cinnamic aldehyde (46.30%) in C. zeylanicum, cis-p-menth-2-en-1-ol (33.88%) and linalyl acetate (13.90%) in O. vulgare, and turmerone (55.43%) in C. longa. The MIC showed significant antimicrobial activity of C. longa essential oil against S. aureus (83.3 ± 14.43 µg/mL). Antipromastigote activity showed IC50 values >500 µg/mL to C. zeylanicum, 308.4 ± 1.402 µg/mL to O. vulgare, and 405.5 ± 1.119 µg/mL to C. longa essential oil. Activity against intracellular amastigote of L. amazonensis showed IC50 of 63.3 ± 1.369 µg/mL and cytotoxic was not observed, resulting in selectivity index higher than 15.79 to parasite. C. longa essential oil decreased nitrite production in peritoneal macrophages, but not in Leishmania-infected cells. The chemical composition of the three essential oils is directly associated to its potential biological action, as the antimicrobial activity. C. longa presented a potent antileishmanial activity against promastigote and intracellular amastigote of L. amazonensis, although this activity is not linked to nitric oxide, since C. longa essential oil inhibits its production.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectCinnamomum zeylanicum
dc.subjectOriganum vulgare
dc.subjectCurcuma longa
dc.subjectÓleos essenciais
dc.subjectComposição química
dc.subjectAtividade Antileishmanial
dc.subjectAtividade antimicrobiana
dc.subjectCinnamomum zeylanicum
dc.subjectOriganum vulgare
dc.subjectCurcuma longa
dc.subjectEssential Oils
dc.subjectAntileishmanial Activity
dc.subjectChemical Composition
dc.subjectAntimicrobial Activity
dc.titleCinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
dc.typeArticle


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