Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay

dc.creatorRego, Natalia
dc.creatorSalazar, Cecilia
dc.creatorPaz, Mercedez
dc.creatorCostábile, Alicia
dc.creatorFajardo, Alvaro
dc.creatorFerrés, Ignacio
dc.creatorPerbolianachis, Paula
dc.creatorFernández-Calero, Tamara
dc.creatorNoya, Veronica
dc.creatorMachado, Matias R.
dc.creatorBrandes, Mariana
dc.creatorArce, Rodrigo
dc.creatorArleo, Mailen
dc.creatorPossi, Tania
dc.creatorReyes, Natalia
dc.creatorBentancor, Maria Noel
dc.creatorLizasoain, Andrés
dc.creatorBortagaray, Viviana
dc.creatorMoller, Ana
dc.creatorChappos, Odhille
dc.creatorNin, Nicolas
dc.creatorHurtado, Javier
dc.creatorDuquía, Melissa
dc.creatorGonzález, Maria Belén
dc.creatorGriffero, Luciana
dc.creatorMéndez, Mauricio
dc.creatorTechera, Maria Pía
dc.creatorZanetti, Juan
dc.creatorPereira, Emiliano
dc.creatorRivera, Bernardina
dc.creatorMaidana, Matías
dc.creatorAlonso, Martina
dc.creatorSmircich, Pablo
dc.creatorArantes, Ighor
dc.creatorMir, Daiana
dc.creatorAlonso, Ceclia
dc.creatorMedina, Julio
dc.creatorAlbornoz, Henry
dc.creatorColina, Rodney
dc.creatorBello, Gonzalo
dc.creatorMoreno, Pilar
dc.creatorMoratorio, Gonzalo
dc.creatorIraola, Gregorio
dc.creatorSpangenberg, Lucía
dc.date2021-12-10T18:37:04Z
dc.date2021-12-10T18:37:04Z
dc.date2021
dc.date.accessioned2023-09-27T00:13:02Z
dc.date.available2023-09-27T00:13:02Z
dc.identifierREGO, Natalia et al. Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay. Viruses, v. 13, 1801, p. 1 - 16, Sept. 2021.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50305
dc.identifier10.3390/v13091801
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898612
dc.descriptionUruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectSARS-CoV-2
dc.subjectEspigão
dc.subjectFilogeografia
dc.subjectFilogenética
dc.subjectUruguai
dc.subjectSARS-CoV-2
dc.subjectB.1.1.28
dc.subjectSpike
dc.subjectQ675H
dc.subjectQ677H
dc.subjectUruguay
dc.subjectPhylogeography
dc.subjectPhylogenetics
dc.titleEmergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay
dc.typeArticle


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