| dc.creator | Pinheiro, Sonia Regina Almeida Alves | |
| dc.creator | Martins Filho, Olindo Assis | |
| dc.creator | Ribas, João Gabriel Rodrigues | |
| dc.creator | Soares, Bernadette Corrêa Catalan | |
| dc.creator | Proietti, Fernando Augusto | |
| dc.creator | Lopes, Sueli Namen | |
| dc.creator | Melo, Gustavo Eustáquio Brito Alvim de | |
| dc.creator | Carneiro, Anna Bárbara Freitas | |
| dc.date | 2013-10-25T13:59:20Z | |
| dc.date | 2013-10-25T13:59:20Z | |
| dc.date | 2006 | |
| dc.date.accessioned | 2023-09-27T00:12:57Z | |
| dc.date.available | 2023-09-27T00:12:57Z | |
| dc.identifier | PINHEIRO, Sonia Regina Almeida Alves et al. Immunologic markers, uveitis, and keratoconjunctivitis sicca associated with human T-cell lymphotropic virus type 1. Am J Ophthalmol. 2006 Nov;142(5):811-15 | |
| dc.identifier | 0002-9394 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/7207 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8898598 | |
| dc.description | PURPOSE:
To verify the occurrence of keratoconjunctivitis sicca (KCS) and human T-cell lymphotropic virus type 1 (HTLV-1) associated uveitis (HAU) and to evaluate the immunologic status related to HTLV-1.
DESIGN:
Cross-sectional study.
METHODS:
Ophthalmic examination (both eyes) and immunophenotyping of peripheral blood lymphocytes were performed in 207 infected asymptomatic blood donors (AS), 55 controls (NI), and 55 patients with HTLV-1 associated myelopathy (HAM/TSP). Examiner was masked to patient's serologic status.
RESULTS:
KCS was more frequent in HAM/TSP (30/55, 54.5%) than in NI and AS (07/55, 12.7% and 42/207, 20.3%, respectively). Presence of lacrimal hyposecretion in KCS individuals was higher in the HAM/TSP group (P < .001) as compared with NI and AS. HAU was found in 1/55 (1.82%) of HAM/TSP patients and 4/207 (1.93%) of HTLV-1 seropositive donors. Higher levels of activated CD4(+) and CD8(+) T cells were observed in HAM/TSP. Patients with HAU displayed higher percentage of both CD4(+) HLA-DR(+) and CD8(+)HLA-DR(+) when compared with NI and AS without HAU.
CONCLUSIONS:
Patients with HAM/TSP manifested more ophthalmologic symptoms than asymptomatic HTLV-1-infected individuals, with significantly higher KCS and immunologic alterations. Levels of activated CD8+ T cells could be used as a prognosis marker of inflammatory disease manifestation to follow-up AS individuals. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier Science | |
| dc.rights | restricted access | |
| dc.subject | leukemia/lymphom | |
| dc.title | Immunologic markers, uveitis, and keratoconjunctivitis sicca associated with human T-cell lymphotropic virus type 1 | |
| dc.type | Article | |
