Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease

dc.creatorSilva, Camilla P. da
dc.creatorAbreu, Gabriella de Medeiros
dc.creatorCabello Acero, Pedro H.
dc.creatorCampos, Mário
dc.creatorPereira, João S.
dc.creatorRamos, Sarah R. de A.
dc.creatorNascimento, Caroline M.
dc.creatorVoigt, Danielle D.
dc.creatorRosso, Ana Lucia
dc.creatorLeite, Marco A. Araujo
dc.creatorVasconcellos, Luiz Felipe R.
dc.creatorNicaretta, Denise H.
dc.creatorDella Coletta, Marcus V.
dc.creatorSilva, Delson José da
dc.creatorGonçalves, Andressa P.
dc.creatorSantos, Jussara M. dos
dc.creatorCalassara, Veluma
dc.creatorValença, Débora Cristina T.
dc.creatorMartins, Cyro J. de M.
dc.creatorRebouças, Cíntia B. Santos
dc.creatorPimentel, Márcia M. G.
dc.date2018-06-01T20:54:23Z
dc.date2018-06-01T20:54:23Z
dc.date2017
dc.date.accessioned2023-09-27T00:12:40Z
dc.date.available2023-09-27T00:12:40Z
dc.identifierSILVA, amilla P. da; et al. Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease. Journal of the Neurological Sciences, v.381, p.160-164, Aug. 2017
dc.identifier0022-510X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26701
dc.identifier10.1016/j.jns.2017.08.3249
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898560
dc.descriptionParkinson's disease (PD) is a neurodegenerative disorder characterized by remarkable phenotypic variability. Accumulated evidence points that the manifestation of PD clinical signs might be differentially modified by genetic factors, as mutations in LRRK2 and GBA genes. In this sense, the clarification of the genotype-phenotype correlations in PD has important implications in predicting prognosis and can contribute to the development of specific therapeutic approaches.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectMal de Parkinson
dc.subjectHeterogeneidade
dc.subjectGenótipos
dc.subjectFenótipos
dc.subjectSerina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina
dc.subjectDoença de Gaucher
dc.subjectParkinson's disease
dc.subjectHeterogeneity
dc.subjectGenotype
dc.subjectPhenotype
dc.subjectLRRK2
dc.subjectGBA
dc.titleClinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease
dc.typeArticle


Este ítem pertenece a la siguiente institución