Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation

dc.creatorFonseca, Érica L.
dc.creatorVicente, Ana Carolina
dc.date2022-10-26T14:29:19Z
dc.date2022-10-26T14:29:19Z
dc.date2022
dc.date.accessioned2023-09-27T00:12:38Z
dc.date.available2023-09-27T00:12:38Z
dc.identifierFONSECA, Érica L. : VICENTE, Ana Carolina. Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation. Microorganisms, v. 10, 224, p. 1 - 34, Jan.. 2022.
dc.identifier2076-2607
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55346
dc.identifier10.3390/ microorganisms10020224
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898556
dc.descriptionIntegrons are considered hot spots for bacterial evolution, since these platforms allow one-step genomic innovation by capturing and expressing genes that provide advantageous novelties, such as antibiotic resistance. The acquisition and shuffling of gene cassettes featured by integrons enable the population to rapidly respond to changing selective pressures. However, in order to avoid deleterious effects and fitness burden, the integron activity must be tightly controlled, which happens in an elegant and elaborate fashion, as discussed in detail in the present review. Here, we aimed to provide an up-to-date overview of the complex regulatory networks that permeate the expression and functionality of integrons at both transcriptional and translational levels. It was possible to compile strong shreds of evidence clearly proving that these versatile platforms include functions other than acquiring and expressing gene cassettes. The well-balanced mechanism of integron expression is intricately related with environmental signals, host cell physiology, fitness, and survival, ultimately leading to adaptation on the demand.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectIntegron
dc.subjectTranscrição
dc.subjectTradução
dc.subjectRegulador global
dc.subjectResposta SOS
dc.subjectAdaptação
dc.subjectInterferência de transcrição
dc.subjectAcoplamento de tradução
dc.subjectAtenuação de tradução
dc.subjectExpressão de cassete gênica
dc.subjectIntegron
dc.subjectTranscription
dc.subjectTranslation
dc.subjectGlobal regulator
dc.subjectSOS response
dc.subjectAdaptation
dc.subjectTranscription interference
dc.subjectTranslation coupling
dc.subjectTranslation attenuation
dc.subjectGene cassette expression
dc.titleIntegron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation
dc.typeArticle


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