GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol

dc.creatorTeles, Amanda Mara
dc.creatorSilva, João Victor Silva
dc.creatorFernandes, Juan Matheus Pereira
dc.creatorSilva, Ana Lucia Abreu
dc.creatorCalabrese, Kátia da Silva
dc.creatorMendes Filho, Nestor Everton
dc.creatorMouchrek, Adenilde Nascimento
dc.creatorSouza, Fernando Almeida
dc.date2021-04-16T15:02:59Z
dc.date2021-04-16T15:02:59Z
dc.date2021
dc.date.accessioned2023-09-27T00:12:34Z
dc.date.available2023-09-27T00:12:34Z
dc.identifierTELES, Amanda Mara et al. GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol. Evidence-Based Complementary and Alternative Medicine, v. 2021, Article ID 666.3255, 12p, Feb. 2021.
dc.identifier1741-427X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/46737
dc.identifier10.1155/2021/6663255
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898543
dc.descriptionSyzygium aromaticum has a diversity of biological activities due to the chemical compounds found in its plant products such as total phenolic compounds and flavonoids. The present work describes the chemical analysis and antimicrobial, antioxidant, and antitrypanosomal activity of the essential oil of S. aromaticum. Eugenol (53.23%) as the major compound was verified by gas chromatography-mass spectrometry. S. aromaticum essential oil was more effective against S. aureus (MIC 50 μg/mL) than eugenol (MIC 250 μg/mL). Eugenol presented higher antioxidant activity than S. aromaticum essential oil, with an EC50 of 12.66 and 78.98 µg/mL, respectively. S. aromaticum essential oil and eugenol exhibited Trypanosoma cruzi inhibitory activity, with IC50 of 28.68 ± 1.073 and 31.97 ± 1.061 μg/mL against epimastigotes and IC50 of 64.51 ± 1.658 and 45.73 ± 1.252 μg/mL against intracellular amastigotes, respectively. Both compounds presented low cytotoxicity, with S. aromaticum essential oil displaying 15.5-fold greater selectivity for the parasite than the cells. Nitrite levels in T. cruzi-stimulated cells were reduced by essential oil (47.01%;  = 0.002) and eugenol (48.05%;  = 0.003) treatment. The trypanocidal activity of S. aromaticum essential oil showed that it is reasonable to use it in future research in the search for new therapeutic alternatives for trypanosomiasis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi
dc.rightsopen access
dc.subjectSyzygium aromaticum
dc.subjectAtividade antibacteriana
dc.subjectAtividade antioxidante
dc.subjectAntitripanossômica
dc.subjectÓleo essencial
dc.subjectEugenol
dc.subjectCaracterização por GC-MS
dc.subjectSyzygium aromaticum
dc.subjectAntibacterial activity
dc.subjectAntioxidant activity
dc.subjectAntitrypanosomal Activity
dc.subjectGC-MS Characterization
dc.subjectEssential Oil
dc.subjectEugenol
dc.titleGC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol
dc.typeArticle


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