Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes

dc.creatorLuna, Karla Patrícia de Oliveira
dc.creatorMelo, Cristiane ML
dc.creatorPascoal, Vanessa Peruhype Magalhães
dc.creatorMartins Filho, Olindo Assis
dc.creatorPereira, Valéria Rêgo Alves
dc.date2014-11-12T12:19:19Z
dc.date2014-11-12T12:19:19Z
dc.date2011
dc.date.accessioned2023-09-27T00:12:33Z
dc.date.available2023-09-27T00:12:33Z
dc.identifierLUNA, Karla Patrícia de Oliveira et al. Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes. International Journal of Interferon, cytokine and mediator research, volume 3 p. 9-18, 2011.
dc.identifier1179-139X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8798
dc.identifier10.2147/IJICMR.S14331
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898541
dc.descriptionSnake venom is a complex biological mixture used for immobilization and killing of prey for alimentation. Many effects are inflicted by this venom, such as coagulation, necrosis, bleeding, inflammation, and shock. This study aimed to evaluate the inflammatory activity promoted by Bothrops erythromelas and Crotalus durissus cascavella snake venom. It was observed that both B. erythromelas and C. d. cascavella venom induced higher interferon-gamma and interleukin-6 production. Nitric oxide (NO) was significantly produced only by B.erythromelas venom, which also showed a higher rate of cell death induction when compared with C. d. cascavella. Results showed that B. erythromelas and C. d. cascavella venom induced distinct response in vitro through cytokines and NO production. However, B. erythromelasinduces a proinflammatory response and a higher rate of cell death in relation to C. d. cascavella venom.
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidade de São Paulo
dc.rightsopen access
dc.subjectsnake venom
dc.subjectBothrops
dc.subjectnitric oxide
dc.subjectnecrosis
dc.subjectCrotalus
dc.titleBothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
dc.typeArticle


Este ítem pertenece a la siguiente institución