Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients

dc.creatorVarandas, Cinthya Maria Neves
dc.creatorSilva, José Lucas Sena da
dc.creatorPrimo, Janeusa Rita Leite
dc.creatorOliveira, Maria de Fátima S. P. de
dc.creatorCarvalho, Otávio Moreno
dc.creatorVallve, Maria Lourdes Farre
dc.creatorBittencourt, Achilea Candida Lisboa
dc.date2019-02-05T13:44:17Z
dc.date2019-02-05T13:44:17Z
dc.date2018
dc.date.accessioned2023-09-27T00:12:24Z
dc.date.available2023-09-27T00:12:24Z
dc.identifierVARANDAS, C. M. N. et al. Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients. Clinical Infectious Diseases, v. 67, n. 9, p. 1427–1433, 2018.
dc.identifier1058-4838
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31421
dc.identifier10.1093/cid/ciy289
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898516
dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [grant number RED0028/2012 to L. F.] and Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq [grant number 409985/2016-3 to A. L. B.].
dc.descriptionHuman T-cell lymphotropic virus type-1 (HTLV-1) may cause severe diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). The clinical characteristics and progression of 25 early onset HAM/TSP associated or not to IDH were described. Methods. Following-up 37 IDH patients with neurological examinations, 54% developed HAM/TSP. To these cases were added 5 cases of juvenile HAM/TSP. The patients were HTLV-1+ and were submitted to dermatological and neurological examinations. Diagnosis of HAM/TSP was performed according to Osame et al (1990) and Castro-Costa et al (2006) criteria. Results. Twenty-one patients were classified as definite HAM/TSP by both criteria, 3 as probable HAM/TSP by Osame et al, and another as probable HAM/TSP according to Castro-Costa et al Median age at onset of neurological manifestations was 9 years for the IDH/HAM/TSP group and 16 years for the HAM/TSP group (P = .045). In 12 patients, the onset of neurological manifestations occurred when they were less than 10 years of age. In the group IDH/HAM/TSP, the neurological symptoms always begun during the period of activity of IDH. The progression of HAM/TSP evaluated in 17 cases was heterogeneous, and 3 had rapid progressive course. Conclusions. The juvenile HAM/TSP may occur very early and also presents marked female predominance. Progression of IDH to HAM/TSP before 19 years of age is frequent (54%). Rapid progressive form may also occur in early HAM/TSP. As juvenile IDH and HAM/TSP are due to vertical transmission through breastfeeding, it is very important to avoid this pathway of infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectHAM / TSP
dc.subjectDermatite infecciosa
dc.subjectAgrupamento de HTLV-1
dc.subjectTransmissão vertical
dc.subjectHTLV-1
dc.subjectHAM/TSP
dc.subjectInfective dermatitis
dc.subjectHTLV-1 clustering
dc.subjectVertical transmission
dc.titleEarly Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients
dc.typeArticle


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