Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease

dc.creatorCurvo, Eduardo O. V.
dc.creatorFerreira, Roberto R.
dc.creatorMadeira, Fabiana S.
dc.creatorAlves, Gabriel F.
dc.creatorChambela, Mayara C.
dc.creatorMendes, Veronica G.
dc.creatorSangenis, Luiz Henrique C.
dc.creatorWaghabi, Mariana C.
dc.creatorSaraiva, Roberto M.
dc.date2018-05-03T13:48:47Z
dc.date2018-05-03T13:48:47Z
dc.date2018
dc.date.accessioned2023-09-27T00:12:22Z
dc.date.available2023-09-27T00:12:22Z
dc.identifierCURVO, Eduardo O. V. et al. Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 4, p. 1-8, 2018.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26235
dc.identifier10.1590/0074-02760170440
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898511
dc.descriptionBACKGROUND: Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS: This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS: TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS: TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectDoença de Chagas
dc.subjectEcocardiografia
dc.subjectFator de necrose tumoral
dc.subjectFator de crescimento transformador beta 1
dc.subjectPeptídeo natriurético cerebral
dc.subjectChagas Disease
dc.subjectTumour necrosis factor
dc.subjectTransforming growth factor beta 1
dc.subjectBrain natriuretic peptide
dc.subjectEchocardiography
dc.titleCorrelation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease
dc.typeArticle


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