Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole

dc.creatorBezerra, Camila Fonseca
dc.creatorAlencar Júnior, José Geraldo de
dc.creatorHonorato, Rosilaine de Lima
dc.creatorSantos, Antonia Thassya Lucas dos
dc.creatorSilva, Josefa Carolaine Pereira da
dc.creatorSilva, Taís Gusmão da
dc.creatorLeal, Antonio Linkoln Alves Borges
dc.creatorRocha, Janaína Esmeraldo
dc.creatorFreitas, Thiago Sampaio de
dc.creatorVieira, Thiago Adler Tavarres
dc.creatorBezerra, Maria Clara Fonseca
dc.creatorSales, Debora Lima
dc.creatorKerntopf, Marta Regina
dc.creatorDelmondes, Gyllyandeson de Araujo
dc.creatorBarbosa Filho, José Maria
dc.creatorPeixoto, Laisla Rangel
dc.creatorPinheiro, Allyson Pontes
dc.creatorRibeiro Filho, Jaime
dc.creatorCoutinho, Henrique Douglas Melo
dc.creatorBraga, Maria Flaviana Bezerra Morais
dc.creatorSilva, Teresinha Gonçalves da
dc.date2020-11-16T11:53:54Z
dc.date2020-11-16T11:53:54Z
dc.date2020
dc.date.accessioned2023-09-27T00:11:57Z
dc.date.available2023-09-27T00:11:57Z
dc.identifierBEZERRA, Camila Fonseca et al. Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole. Chemistry and Physics of Lipids, v. 233, 2020.
dc.identifier0009-3084
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44427
dc.identifier10.1016/j.chemphyslip.2020.104987
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898436
dc.descriptiona Department of Pharmaceutical Sciences, Federal University of Pernambuco- UFPE, Recife, PE, Brazil b Department of Pharmacy, Federal University of Ceara´- UFC, Fortaleza, CE, Brazil c Department of Biological Sciences, Regional University of Cariri- URCA, Crato, CE, Brazil d Department of Biological Chemistry, Regional University of Cariri- URCA, Crato, CE, Brazil e Faculty of Medicine of Juazeiro do Norte- Esta´cio FMJ, Juazeiro do Norte- CE, Brazil f Department of Pharmacy, Federal University of Paraíba- UFPB, Joa˜o Pessoa, PB, Brazil g Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil h Department of Antibiotics, Federal University of Pernambuco- UFPE, Recife, PE, Brazil
dc.descriptionCandida infections represent a threat to human health. Candida albicans is the main causative agent of invasive candidiasis, especially in immunosuppressed patients. The emergence of resistant strains has required the development of new therapeutic strategies. In this context, the use of liposomes as drug carrier systems is a promising alternative in drug development. Thus, considering the evidence demonstrating that sesquiterpene farnesol is a bioactive compound with antifungal properties, this study evaluated the activity farnesol-containing liposomes against different Candida strains. The IC50 of farnesol and its liposomal formulation was assessed in vitro using cultures of Candida albicans, Candida tropicalis, and Candida krusei. The Minimum Fungicidal Con- centration (MFC) was established by subculture in solid medium. The occurrence of fungal dimorphism was analyzed using optical microscopy. The effects on antifungal resistance to fluconazole were assessed by evalu- ating the impact of combined therapy on the growth of Candida strains. The characterization of liposomes was carried out considering their vesicular size, polydispersion index, and zeta medium potential, in addition to electron microscopy analysis. Farnesol exerted an antifungal activity that might be associated with the inhibition of fungal dimorphism, especially in Candida albicans. The incorporation of farnesol into liposomes significantly increased its antifungal activity against C. albicans, C. tropicalis, and C. krusei. In addition, liposomal farnesol potentiated the action of fluconazole against C. albicans and C. tropicalis. On the other hand, the association of unconjugated farnesol with fluconazole resulted in antagonistic effects. In conclusion, farnesol-containing li- posomes have the potential to be used in antifungal drug development. However, further research is required to investigate how the antifungal properties of farnesol are affected by the interaction with liposomes, contributing to the modulation of antifungal resistance to conventional drugs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectFarnesol
dc.subjectLipossomas
dc.subjectFluconazol
dc.subjectCandida
dc.subjectAnticorpos Antifúngicos
dc.subjectFarnesol
dc.subjectLiposomes
dc.subjectFluconazole
dc.subjectCandida dimorphism
dc.subjectAntifungal effect
dc.titleAntifungal activity of farnesol incorporated in liposomes and associated with fluconazole
dc.typeArticle


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