18-Des-hydroxy Cytochalasin: an antiparasitic compound of Diaporthe phaseolorum-92C, an endophytic fungus isolated from Combretum lanceolatum Pohl ex Eichler

dc.creatorBrissow, Elson Rudimar
dc.creatorSilva, Igor Pereira da
dc.creatorSiqueira, Kátia Aparecida de
dc.creatorSenabio, Jaqueline Alves
dc.creatorPimenta, Leticia Pereira
dc.creatorJanuário, Ana Helena
dc.creatorMagalhães, Lizandra Guidi
dc.creatorFurtado, Ricardo Andrade
dc.creatorTavares, Denise Crispim
dc.creatorSales Junior, Policarpo Ademar
dc.creatorSantos, Jane Lima
dc.creatorSoares, Marcos Antônio
dc.date2019-08-27T18:26:40Z
dc.date2019-08-27T18:26:40Z
dc.date2017
dc.date.accessioned2023-09-27T00:11:33Z
dc.date.available2023-09-27T00:11:33Z
dc.identifierBRISSOW, Elson Rudimar et al. 18-Des-hydroxy Cytochalasin: an antiparasitic compound of Diaporthe phaseolorum-92C, an endophytic fungus isolated from Combretum lanceolatum Pohl ex Eichler. Parasitology Research, v. 116, n. 7, p. 1823-1830, 2017.
dc.identifier0932-0113
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/35143
dc.identifier10.1007/s00436-017-5451-9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898367
dc.descriptionChemical investigation of the ethyl acetate extract from the endophytic fungus Diaporthe phaseolorum-92C (92C) isolated from the roots of Combretum lanceolatum led to the isolation of 18-des-hydroxy Cytochalasin H (compound 1). The trypanocidal and schistosomicidal activity and cytotoxicity of the extract from 92C were evaluated. The schistosomicidal, leishmanicidal, antimicrobial, and antioxidant actions, as well as the antitumor activity against the breast cancer cells MDA-MB-231 and MCF-7, and the cytotoxicity towards normal human lung fibroblasts GM07492A of compound 1 was tested. The extract from 92C (20 μg/mL) exerted potent trypanocidal activity, reducing 82% of the number of amastigotes and trypomastigotes of Trypanosoma cruzi. Compound 1 at 50 μg/mL killed 50% of Schistosoma mansoni adult worms. Compound 1 reduced the viability of Leishmania amazonenses promastigotes (IC50 = 9.2 μg/mL) and of the cancer cells MDA-MB-231 and MCF-7 (IC50 = 17.5 and 8.88 μg/mL, respectively), presented moderate antioxidant activity, and gave IC50 of 2049.7 ± 39.9 μg/mL for the cytotoxicity towards normal cells GM07492A. This knowledge is highly relevant to the search for new promising compounds for therapeutic purposes.
dc.description2100-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer International
dc.rightsrestricted access
dc.subjectCombretum lanceolatum
dc.subjectEndophytic fungi
dc.subjectDiaporthe phaseolorum
dc.subjectCytochalasin
dc.subjectAntioxidant
dc.subjectAntitumor
dc.subjectLeishmanicidal
dc.subjectSchistosomicidal
dc.title18-Des-hydroxy Cytochalasin: an antiparasitic compound of Diaporthe phaseolorum-92C, an endophytic fungus isolated from Combretum lanceolatum Pohl ex Eichler
dc.typeArticle


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