Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease

dc.creatorSilva, Jaquelline Carla Valamiel de Oliveira
dc.creatorAssis, Girley Francisco Machado de
dc.creatorOliveira, Maykon Tavares
dc.creatorPaiva, Nívia Carolina Nogueira
dc.creatorAraújo, Márcio Sobreira Silva
dc.creatorCarneiro, Cláudia Martins
dc.creatorMartins Filho, Olindo Assis
dc.creatorMartins, Helen Rodrigues
dc.creatorLana, Marta de
dc.date2016-01-20T14:27:56Z
dc.date2016-01-20T14:27:56Z
dc.date2015
dc.date.accessioned2023-09-27T00:11:31Z
dc.date.available2023-09-27T00:11:31Z
dc.identifierSILVA, Jaquelline Carla Valamiel de Oliveira et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Mem Inst Oswaldo Cruz, Vol. 110, n. 1, p. 86-94, 2015.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12567
dc.identifier10.1590/0074-02760140260
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898361
dc.descriptionTrypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectTrypanosoma cruzi II
dc.subjectbenznidazole response
dc.subjectacute and chronic phases
dc.subjectmurine model
dc.subjectJequitinhonha Valley - MG - Brazil
dc.titleExperimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
dc.typeArticle


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