Serum IgA Antibodies Specific to M. leprae Antigens as Biomarkers for Leprosy Detection and Household Contact Tracking

dc.creatorSilva, Kyssia Karen de Paiva e
dc.creatorOliveira, Erick Esteves de
dc.creatorElias, Carolina Martins Moreira
dc.creatorPereira, Ingrid Estevam
dc.creatorPinheiro, Roberta Olmo
dc.creatorSarno, Euzenir Nunes
dc.creatorDuthie, Malcolm Scott
dc.creatorTeixeira, Henrique Couto
dc.date2022-02-08T17:48:45Z
dc.date2022-02-08T17:48:45Z
dc.date2021
dc.date.accessioned2023-09-27T00:10:57Z
dc.date.available2023-09-27T00:10:57Z
dc.identifierSILVA, Kyssia Karen de Paiva e et al. Serum IgA Antibodies Specific to M. leprae Antigens as Biomarkers for Leprosy Detection and Household Contact Tracking. Frontiers in Medicine, v. 8, Article 698495, p. 1 - 7, Aug. 2021.
dc.identifier2298-858X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51085
dc.identifier10.3389/fmed.2021.698495
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898267
dc.descriptionLeprosy remains endemic in several developing countries, such as India and Brazil, in part due to delayed diagnosis that facilitates ongoing transmission. Although immunoglobulins against severalMycobacteriumleprae antigens have been indicated for the early diagnosis, and IgA participates in the early stages of leprosy and in subclinical infection, relatively little research has examined anti-M. leprae IgA responses. Here, we investigated serumIgA reactivity against NDO-HSA, LID-1 and NDO-LID, in paucibacillary (PB) and multibacillary (MB) patients and their household contacts, using enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy of each ELISA was evaluated by receiver operating characteristic (ROC) curve analysis. Our data reveal elevated IgA serum levels against the three M. leprae specific antigens in MB patients, whereas IgA reactivity in PB patients was increased only to NDO-HSA. Further, MB and PB household contacts displayed higher IgA reactivity to NDO-HSA than non-endemic controls. Our data suggestmeasurement of serumIgA against NDO-HSA as an additional tool in the diagnosis and classification of the disease, with potential utility for household contact follow-up.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectHanseníase
dc.subjectDiagnóstico
dc.subjectBioomarcador
dc.subjectIgA
dc.subjectNDO-HSA
dc.subjectLID-1
dc.subjectCaracterísticas operacionais do receptor
dc.subjectContato doméstico
dc.subjectLeprosy
dc.subjectDiagnosis
dc.subjectIgA
dc.subjectNDO-HSA
dc.subjectLID-1
dc.subjectROC analysis
dc.subjectHousehold contact
dc.subjectBiomarker
dc.titleSerum IgA Antibodies Specific to M. leprae Antigens as Biomarkers for Leprosy Detection and Household Contact Tracking
dc.typeArticle


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