Naturally Acquired Antibodies to Plasmodium vivax Duffy Binding Protein (DBP) in Rural Brazilian Amazon.

dc.contributorAmerican Society of Tropical Medicine and Hygiene
dc.creatorSilva, Flavia Alessandra de Souza
dc.creatorSanchez, Bruno Antonio Marinho
dc.creatorCerávolo, Isabela Penna
dc.creatorBrito, Cristiana Ferreira Alves de
dc.creatorCarvalho, Luzia Helena de
dc.creatorNunes, Mônica da Silva
dc.creatorFerreira, Marcelo Urbano
dc.creatorMalafronte, Rosely dos Santos
dc.date2013-10-03T16:08:12Z
dc.date2013-10-03T16:08:12Z
dc.date2010
dc.date.accessioned2023-09-27T00:10:45Z
dc.date.available2023-09-27T00:10:45Z
dc.identifierSOUZA SILVA, Flávia A et al. Naturally Acquired Antibodies to Plasmodium vivax Duffy Binding Protein (DBP) in Rural Brazilian Amazon. Am J Trop Med Hyg. 2010 February; 82(2): 185–193.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7078
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898234
dc.descriptionDuffy binding protein (DBP), a leading malaria vaccine candidate, plays a critical role in Plasmodium vivax erythrocyte invasion. Sixty-eight of 366 (18.6%) subjects had IgG anti-DBP antibodies by enzyme-linked immunosor bent assay (ELISA) in a community-based cross-sectional survey in the Brazilian Amazon Basin. Despite continuous exposure to low-level malaria transmission, the overall seroprevalence decreased to 9.0% when the population was reexamined 12 months later. Antibodies from 16 of 50 (36.0%) subjects who were ELISA-positive at the baseline were able to inhibit erythrocyte binding to at least one of two DBP variants tested. Most (13 of 16) of these subjects still had inhibitory anti-bodies when reevaluated 12 months later. Cumulative exposure to malaria was the strongest predictor of DBP seroposi-tivity identified by multiple logistic regression models in this population. The poor antibody recognition of DBP elicited by natural exposure to P. vivaxin Amazonian populations represents a challenge to be addressed by vaccine development strategies.
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectDuffy binding protein
dc.subjectmalaria vaccine
dc.titleNaturally Acquired Antibodies to Plasmodium vivax Duffy Binding Protein (DBP) in Rural Brazilian Amazon.
dc.typeArticle


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