Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.

dc.creatorKashima, Simone G
dc.creatorAlcantara, Luiz Carlos Júnior
dc.creatorTakayanagui, Osvaldo Massaiti
dc.creatorCunha, Marco Aurelio Valtas
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorOliveira, Maria Socorro Pombo de
dc.creatorZago, Marco Antonio
dc.creatorCovas, Dimas Tadeu
dc.date2014-08-04T18:08:19Z
dc.date2014-08-04T18:08:19Z
dc.date2006
dc.date.accessioned2023-09-27T00:10:41Z
dc.date.available2023-09-27T00:10:41Z
dc.identifierKASHIMA, S. et al. Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. AIDS Reserach Human and Retroviruses, v. 22, n. 10, p. 953-599, 2006.
dc.identifier0889-2229
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8123
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898222
dc.descriptionWe report the molecular and epidemiological characterization of 128 human T cell lymphotropic virus type 1 (HTLV-1) isolates from Brazilian patients with different clinical manifestations of the infection. Thirty-two percent of the patients were asymptomatic, 44% had HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and 23% had adult T cell leukemia/lymphoma (ATLL). Phylogenetic analysis performed using part of the LTR region of the viral genome revealed that all Brazilian isolates belonged to the Cosmopolitan subtype, with the following distribution within the Transcontinental subgroup: 81.6% within the Latin American cluster and 15.8% outside the Latin American cluster. Two isolates belonged to the Japanese subgroup. Molecular analysis of the tax region showed a high nucleotide similarity ( 99%) with 41 prototype sequences, including the ATK-1 isolate. The mean number of nucleotide substitutions ranged from 1 to 8. Five specific nucleotide substitutions, C7401T, T7914C, C7920T, C7982T, and G8231A, were highly conserved among the Brazilian isolates (79.6%), with a frequency ranging from 81.6% to 100% in the sample group and from 18.4% to 24.1% in the prototypes used, suggesting the existence of a molecular signature. These changes were not correlated with a specific clinical status of the patients and could be a molecular characteristic of the HTLV-1 strains that circulate in Brazil.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMary Ann Liebert, Inc
dc.rightsopen access
dc.subjectGenes pX/genética
dc.subjectVírus 1 Linfotrópico T Humano/genética
dc.subjectSequências Repetidas Terminais/genética
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectBrasil/epidemiologia
dc.subjectFeminino
dc.subjectInfecções por HTLV-I/epidemiologia
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectEpidemiologia Molecular
dc.subjectDados de Sequência Molecular
dc.titleDistribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
dc.typeArticle


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