Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary

dc.creatorPrevatto, Jessika P.
dc.creatorTorres, Rafael C.
dc.creatorDiaz, Bruno L.
dc.creatorSilva, Patrícia M. R. e
dc.creatorMartins, Marco A.
dc.creatorCarvalho, Vinicius F.
dc.date2017-06-29T15:56:22Z
dc.date2017-06-29T15:56:22Z
dc.date2017
dc.date.accessioned2023-09-27T00:10:29Z
dc.date.available2023-09-27T00:10:29Z
dc.identifierPREVATTO, Jessika P. et al. Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary. Oxidative Medicine and Cellular Longevity, Vol. 2017, Article ID 4156361, 10p, 2017
dc.identifier1942-0900
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19675
dc.identifier10.1155/2017/4156361
dc.identifier1942-0994
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898187
dc.descriptionGlucocorticoid (GC) production is physiologically regulated through a negative feedback loop mediated by the GC, which appear disrupted in several pathological conditions. The inability to perform negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in several diseases is associated with an overproduction of reactive oxygen species (ROS); however, nothing is known about the effects of ROS on the functionality of the HPA axis during homeostasis. This study analyzed the putative impact of antioxidants on the HPA axis activity and GC-mediated negative feedback upon the HPA cascade. Male Wistar rats were orally treated with N-acetylcysteine (NAC) or vitamin E for 18 consecutive days. NAC-treated rats were then subjected to a daily treatment with dexamethasone, which covered the last 5 days of the antioxidant therapy. We found that NAC and vitamin E induced an increase in plasma corticosterone levels. NAC intensified MC2R and StAR expressions in the adrenal and reduced GR and MR expressions in the pituitary. NAC also prevented the dexamethasone-induced reduction in plasma corticosterone levels. Furthermore, NAC decreased HO-1 and Nrf2 expression in the pituitary. These findings show that antioxidants induce hyperactivity of the HPA axis via upregulation of MC2R expression in the adrenal and downregulation of GR and MR in the pituitary.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectTratamento com antioxidantes
dc.subjectGlândulas Suprarrenais
dc.subjectSistema Hipófise-Suprarrenal
dc.subjectReceptores de Glucocorticoides
dc.subjectGlucocorticoid Receptors
dc.subjectAntioxidant Treatment
dc.subjectHPA
dc.subjectHyperactivation
dc.subjectPituitary-Adrenal System
dc.titleAntioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary
dc.typeArticle


Este ítem pertenece a la siguiente institución