Long-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea

dc.creatorOliveira, Geraldo Gileno de Sá
dc.creatorHolton, John
dc.creatorLydyard, Peter M
dc.date2011-03-26T17:46:03Z
dc.date2011-03-26T17:46:03Z
dc.date2010
dc.date.accessioned2023-09-27T00:10:27Z
dc.date.available2023-09-27T00:10:27Z
dc.identifierOLIVEIRA, G. G. de S.; HOLTON, J.; LYDYARD, P. M. Long-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea. Gut Microbes, v. 1, n. 5, p. 345-355, 2010.
dc.identifier21327045
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/1751
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898182
dc.descriptionIn this paper, we have shown that long-term treatment of NZB mice with anti-CD4 antibody results in four major pathological effects: firstly the development of a severe wasting disease; secondly lymphoid atrophy of the thymus, spleen, mesenteric lymph node and Peyers patches (PP); thirdly, severe chronic ulcerative colitis and fourthly a neutrophilia with neutrophil infiltration in the spleen, liver and mesenteric lymph nodes. At the same time, mice subjected to anti-CD4 treatment showed a reduction in the microbial diversity in ileal walls and contents, as well as in colonic contents, together with overgrowth of E. coli in the intestinal lumen and wall. In addition, there was the appearance of large numbers of spiral shaped bacteria on the mucosal surface often associated with colonic ulceration.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLandes Bioscience
dc.rightsopen access
dc.subjectDiareia cronica
dc.subjectAnti-CD4
dc.subjectModelo animal
dc.subjectCamundongos NZB
dc.subjectanti-CD4
dc.subjectChronic Diarrhea
dc.subjectAnimal model
dc.subjectNZB mice
dc.subjectHelical bacteria
dc.subjectAntígenos CD4
dc.subjectDiarreia
dc.subjectEscherichia coli
dc.subjectCamundongos Endogâmicos NZB
dc.subjectModelos animais
dc.titleLong-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea
dc.typeArticle


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