Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.

dc.creatorSiqueira, Ana Cristina Guidorizzi de
dc.creatorCotrim, Helma Pinchemel
dc.creatorRocha, Raquel
dc.creatorCarvalho, Fernando Martins
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorBarreto, Danyella
dc.creatorGouveia, Leandro
dc.creatorLandeiro, Luciana
dc.date2014-07-08T14:23:37Z
dc.date2014-07-08T14:23:37Z
dc.date2005
dc.date.accessioned2023-09-27T00:10:13Z
dc.date.available2023-09-27T00:10:13Z
dc.identifierGUIDORIZZI DE SIQUEIRA, A. C. et al. Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum. European Journal of Gastroenterology & Hepatology, v. 17, n. 8, p. 837-841, 2005.
dc.identifier0954-691X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7880
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898139
dc.descriptionBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been associated with several metabolic conditions (MC) and secondary causes, but the relationship between insulin resistance (IR) and the underlying aetiology of NAFLD has not been extensively explored. OBJECTIVE: To determine the frequency of IR among NAFLD patients and to describe IR according to risk factors and histological findings of the disease. METHODOLOGY: A case-series study of 64 patients with clinical and histological diagnosis of NAFLD. IR was calculated by homeostasis model assessment (HOMA) and IR was considered when HOMA > or = 3. Histological grades of NAFLD were: stage 1, steatosis isolated; stage 2, steatosis and inflammation; stage 3, steatosis and ballooning degeneration; stage 4, steatosis and fibrosis and/or Mallory bodies. Fibrosis was graded 0-4 (cirrhosis). RESULTS: IR was found in 21 (33%) patients. Among those with IR, 16 patients (76%) had associated MC and five patients (24%) had exposure to petrochemicals. The mean value of HOMA varied from 3.5 in NAFLD associated with MC to 1.6 in patients with exposure to petrochemicals (P < 0.03). Waist circumference was the metabolic factor most strongly associated with IR (P < 0.005). Steatohepatitis (NASH) was observed in 54 (84.3%) cases. The HOMA mean value was significantly higher in patients with advanced fibrosis. CONCLUSIONS: IR occurred in 33% of the NAFLD patients, being more frequent among those with MC than among those with exposure to petrochemicals. The presence of IR in cases with advanced fibrosis suggests that it may influence the prognosis of NAFLD.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.rightsopen access
dc.subjectNon-alcoholic fatty liver disease
dc.subjectNon-alcoholic steatohepatitis
dc.subjectInsulin resistance
dc.subjectFígado Gorduroso/fisiopatologia
dc.subjectResistência à Insulina/fisiologia
dc.subjectAdulto
dc.subjectDoença Crônica
dc.subjectFígado Gorduroso/sangue
dc.subjectFígado Gorduroso/patologia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectCirrose Hepática/sangue
dc.subjectCirrose Hepática/patologia
dc.subjectCirrose Hepática/fisiopatologia
dc.subjectMasculino
dc.subjectSíndrome X Metabólica/sangue
dc.subjectSíndrome X Metabólica/patologia
dc.subjectSíndrome X Metabólica/fisiopatologia
dc.subjectMeia-Idade
dc.subjectFatores de Risco
dc.titleNon-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
dc.typeArticle


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