The Blessed Union of Glycobiology and Immunology: A Marriage That Worked

dc.creatorReis, Jhenifer Santos dos
dc.creatorLima, Israel Diniz
dc.creatorSantos, Marcos André Rodrigues da Costa
dc.creatorBarcelos, Pedro Marçal
dc.creatorCosta, Kelli Monteiro da
dc.creatorValente, Raphael do Carmo
dc.creatorChaves, Lorrane de Souza
dc.creatorCampos, Luma Petel de
dc.creatorSantos, Ariely Costa dos
dc.creatorLima, Rafaela Gomes Correia de
dc.creatorRicardo, Debora Decote
dc.creatorMorrot, Alexandre
dc.creatorPreviato, Jose Osvaldo
dc.creatorPreviato, Lucia Mendonça
dc.creatorLima, Celio Geraldo Freire de
dc.creatorFonseca, Leonardo Marques da
dc.creatorLima, Leonardo Freire de
dc.date2023-04-26T21:36:33Z
dc.date2023-04-26T21:36:33Z
dc.date2023
dc.date.accessioned2023-09-27T00:10:08Z
dc.date.available2023-09-27T00:10:08Z
dc.identifierJheniferSantos dos Reis et al. The Blessed Union of Glycobiology and Immunology: A Marriage That Worked. Medicine, v. 10, 15, p. 1 - 18, 2023.
dc.identifier2305-6320
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58019
dc.identifier10.3390/ medicines10020015
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898125
dc.descriptionAbstract: In this article, we discuss the main aspects regarding the recognition of cell surface glycoconjugates and the immunomodulation of responses against the progression of certain pathologies, such as cancer and infectious diseases. In the first part, we talk about different aspects of glycoconjugates and delve deeper into the importance of N-glycans in cancer immunotherapy. Then, we describe two important lectin families that have been very well studied in the last 20 years. Examples include the sialic acid-binding immunoglobulin (Ig)-like lectins (siglecs), and galectins. Finally, we discuss a topic that needs to be better addressed in the field of glycoimmunology: the impact of oncofetal antigens on the cells of the immune system. New findings in this area are of great importance for advancement, especially in the field of oncology, since it is already known that cellular interactions mediated by carbohydrate–carbohydrate and/or carbohydrate proteins are able to modulate the progression of different types of cancer in events that compromise the functionality of the immune responses.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectGlicoimunologia
dc.subjectGlicoconjugados
dc.subjectLectinas
dc.subjectGalectinas
dc.subjectSiglecs
dc.subjectAntígenos oncofetais
dc.subjectGlycoimmunology
dc.subjectGlycoconjugates
dc.subjectLectins
dc.subjectGalectins
dc.subjectSiglecs
dc.subjectOncofetal antigens
dc.titleThe Blessed Union of Glycobiology and Immunology: A Marriage That Worked
dc.typeArticle


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