NFR1 plays a critical role in the control of severe HSV-1 encephalitis. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis.

dc.creatorVilela, Márcia Carvalho
dc.creatorLima, Graciela Kunrath
dc.creatorRodrigues, David Henrique
dc.creatorQueiroz, Norinne Lacerda
dc.creatorMansur, Daniel Santos
dc.creatorMiranda, Aline Silva de
dc.creatorRachid, Milene Alvarenga
dc.creatorKroon, Erna Geessien
dc.creatorVieira, Leda Quércia
dc.creatorCampos, Marco Antônio da Silva
dc.creatorTeixeira, Mauro Martins
dc.creatorTeixeira, Antônio Lúcio
dc.date2013-10-03T19:27:17Z
dc.date2013-10-03T19:27:17Z
dc.date2010
dc.date.accessioned2023-09-27T00:10:01Z
dc.date.available2023-09-27T00:10:01Z
dc.identifierVILELA, Márcia Carvalho et al. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis. Neurosci Lett., v. 479, n. 1, p. 58-62, Jul. 2010.
dc.identifier0304-3940
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7085
dc.identifier10.1016/j.neulet.2010.05.028
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898106
dc.descriptionHerpes simplex virus-1 (HSV-1) is a pathogen for humans that may cause severe encephalitis. Tumor necrosis factor (TNF- ) plays a role in several viral diseases of the central nervous system (CNS). The classic proinflammatory activities of TNF- are mediated mainly through activation of the receptor 1 for TNF- (TNFR1). However, when HSV-1 is inoculated in the periphery, TNF- seems to protect C57Bl/6 mice against encephalitis by a mechanism independent of TNFR1. This study aims to investigate the role of TNFR1 in HSV-1 encephalitis induced by the inoculation of the virus into the brain. Wild-type C57BL/6 (WT) and TNFR1 −/− were inoculated with 102 plaque-forming units of HSV-1 by the intracranial route. Infection with HSV-1 was lethal in TNFR1 −/− mice in early times after infection. TNFR1−/− mice had reduced expression of the chemokines CCL3 and CCL5, and decreased leukocyte adhesion in the brain vasculature compared to WT mice 4 days post-infection (dpi). At this time point TNFR1 −/− infected mice also had higher HSV-1 viral replication and more injuries in the brain, especially in the hippocampus. In conclusion, TNFR1 seems to play a relevant role in the control of viral replication in the CNS when HSV-1 is inoculated by intracranial route.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Ireland Ltd
dc.rightsrestricted access
dc.subjectHerpes simplex virus type 1
dc.subjectTNFR1
dc.subjectNeuroinflammation
dc.titleNFR1 plays a critical role in the control of severe HSV-1 encephalitis. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis.
dc.typeArticle


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