| dc.creator | Bello, Gonzalo | |
| dc.creator | Afonso, Joana Morais | |
| dc.creator | Morgado, Mariza G. | |
| dc.date | 2016-09-15T15:10:09Z | |
| dc.date | 2016-09-15T15:10:09Z | |
| dc.date | 2012 | |
| dc.date.accessioned | 2023-09-27T00:09:53Z | |
| dc.date.available | 2023-09-27T00:09:53Z | |
| dc.identifier | BELLO, Gonzalo; AFONSO, Joana Morais; MORGADO, Mariza G. Phylodynamics of HIV-1 subtype F1 in Angola, Brazil and Romania. Infection, Genetics and Evolution, v.12, p.1079-1086, 2012. | |
| dc.identifier | 1567-1348 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/15813 | |
| dc.identifier | 10.1016/j.meegid.2012.03.014 | |
| dc.identifier | 1567-7257 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8898083 | |
| dc.description | The HIV-1 subtype F1 is exceptionally prevalent in Angola, Brazil and Romania. The epidemiological context in which the spread of HIV occurred was highly variable from one country to another, mainly due to the existence of a long-term civil war in Angola and the contamination of a large number of children in Romania. Here we apply phylogenetic and Bayesian coalescent-based methods to reconstruct the phylodynamic patterns of HIV-1 subtype F1 in such different epidemiological settings. The phylogenetic analyses of HIV-1 subtype F1 pol sequences sampled worldwide confirmed that most sequences from Angola, Brazil and Romania segregated in country-specific monophyletic groups, while most subtype F1 sequences from Romanian children branched as a monophyletic sub-cluster (Romania-CH) nested within sequences from adults. The inferred time of the most recent common ancestor of the different subtype F1 clades were as follow: Angola=1983 (1978-1989), Brazil=1977 (1972-1981), Romania adults=1980 (1973-1987), and Romania-CH=1985 (1978-1989). All subtype F1 clades showed a demographic history best explained by a model of logistic population growth. Although the expansion phase of subtype F1 epidemic in Angola (mid 1980s to early 2000s) overlaps with the civil war period (1975-2002), the mean estimated growth rate of the Angolan F1 clade (0.49 year(-1)) was not exceptionally high, but quite similar to that estimated for the Brazilian (0.69 year(-1)) and Romanian adult (0.36 year(-1)) subtype F1 clades. The Romania-CH subtype F1 lineage, by contrast, displayed a short and explosive dissemination phase, with a median growth rate (2.47 year(-1)) much higher than that estimated for adult populations. This result supports the idea that the AIDS epidemic that affected the Romanian children was mainly caused by the spread of the HIV through highly efficient parenteral transmission networks, unlike adult populations where HIV is predominantly transmitted through sexual route. | |
| dc.description | 2030-01-01 | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | restricted access | |
| dc.subject | HIV-1 subtipo F1 | |
| dc.subject | HIV-1 | |
| dc.subject | Angola | |
| dc.subject | Brasil | |
| dc.subject | Romênia | |
| dc.subject | História demográfica | |
| dc.subject | HIV-1 | |
| dc.subject | Subtype F1 | |
| dc.subject | Angola | |
| dc.subject | Brazil | |
| dc.subject | Romania | |
| dc.subject | Demographic history | |
| dc.title | Phylodynamics of HIV-1 subtype F1 in Angola, Brazil and Romania | |
| dc.type | Article | |
