Antibodies to Schistosoma mansoni in human cerebrospinal fluid

Antibodies to Schistosoma mansoni in human cerebrospinal fluid

dc.creatorSantos, Isis Fernandes Magalhães
dc.creatorLemaire, Denise Carneiro
dc.creatorAndrade Filho, Antonio de Souza
dc.creatorQueiroz, Aristides Cheto de
dc.creatorCarvalho, Otavio Augusto Moreno
dc.creatorCarmo, Theomira Mauadie de Azevedo
dc.creatorSiqueira, Isadora Cristina de
dc.creatorAndrade, Débora M
dc.creatorRego, Michely F
dc.creatorGuedes, Ana Paula Torres
dc.creatorReis, Mitermayer Galvão dos
dc.date2012-07-13T19:44:56Z
dc.date2012-07-13T19:44:56Z
dc.date2003
dc.date.accessioned2023-09-27T00:09:52Z
dc.date.available2023-09-27T00:09:52Z
dc.identifierMAGALHÃES-SANTOS, I.F. et al. Antibodies to Schistosoma mansoni in human cerebrospinal fluid. American Journal of Tropical Medicine and Hygiene, v. 68, n. 3, p. 294-8, mar. 2003.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/4162
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898081
dc.descriptionCerebrospinal fluid (CSF) and serum samples from patients suspected of having neuroschistosomiasis (NS) were evaluated by an enzyme-linked immunosorbent assay. Monoclonal antibodies of various immunoglobulin isotypes (IgM, IgA, IgE, total IgG, IgG1, IgG2, IgG3, and IgG4) were used to detect antibodies against Schistosoma mansoni soluble egg antigen (SEA) and soluble worm adult preparation (SWAP). Of the 83 CSF samples tested, 55% were reactive toSEA (26% were reactive only toSEA and 29% tobo th SEA and SWAP), 34% were reactive toSWAP (5% only to SWAP and 29% to both SEA and SWAP), and 40% were not reactive with any antigen. Cases that tested positive for SWAP in CSF and negative in serum were not found. Samples with high specific IgG antibody titers were selected for immunoglobulin isotype profiling. In the CSF samples, the antibodies against SEA and SWAP were mainly IgM, IgG1, and IgG4, although other immunoglobulins were also detected. Interestingly, nine patients had high levels of IgG1 only in the CSF. These results suggest that there is local synthesis of IgG1, and that this isotype could be an important immunologic marker in the diagnosis of NS.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAnticorpos Anti-Helmínticos/líquido cefalorraquidiano
dc.subjectDoenças do Sistema Nervoso/líquido cefalorraquidiano
dc.subjectSchistosoma mansoni/imunologia
dc.subjectEsquistossomose/líquido cefalorraquidiano
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectIsotipos de Imunoglobulinas/imunologia
dc.subjectDoenças do Sistema Nervoso/parasitologia
dc.subjectEsquistossomose/parasitologia
dc.titleAntibodies to Schistosoma mansoni in human cerebrospinal fluid
dc.titleAntibodies to Schistosoma mansoni in human cerebrospinal fluid
dc.typeArticle


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