HIV specific humoral immune response in Rio de Janeiro, Brazil. The HEC/Fiocruz AIDS Clinical Research Group.

dc.creatorBongertz, Vera
dc.creatorCosta, Catia Ines
dc.creatorGuimarães, Monick Lindenmeyer
dc.creatorCosta, M. F. G. Soares da
dc.creatorGrinsztejn, Beatriz
dc.creatorThe HEC/Fiocruz AIDS Clinical Research Group
dc.creatorBastos, Francisco Inácio Pinkusfeld Monteiro
dc.creatorPilotto, José Henrique
dc.creatorJoão Filho, Esaú Custódio
dc.creatorLoureiro, Regina
dc.creatorChequer, P
dc.creatorTelles, P. R
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorMorgado, Mariza Gonçalves
dc.date2014-08-12T16:58:39Z
dc.date2014-08-12T16:58:39Z
dc.date1998
dc.date.accessioned2023-09-27T00:08:58Z
dc.date.available2023-09-27T00:08:58Z
dc.identifierBONGERTZ, V. et al. HIV specific humoral immune response in Rio de Janeiro, Brazil. The HEC/Fiocruz AIDS Clinical Research Group. Memórias do Instituto Oswaldo Cruz, v. 93, n. 3, p. 391-398, 1998.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8191
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897923
dc.descriptionEfforts to characterize HIV-1 polymorphism and anti-HIV immune response are being made in areas where anti-HIV/AIDS vaccines are to be employed. Anti-HIV-1 humoral immune response is being studied in infected individuals residents in Rio de Janeiro, in distinct cohorts involving recent seroconvertors, pregnant women or intravenous drug users (IDU). Comparative analyses of specificity of antibody response towards epitopes important for anti-HIV-1 immune response indicate quantitative differences between cohorts, with an exceptionally strong response in IDUs and weakest response in pregnant women. However, a comparative analysis between pregnant women cohorts from Rio de Janeiro and Rio Grande do Sul indicated an even lower response (with exception of the anti-V3-C clade peptide recognition) for the southern cohort. Studies analysing the immune function of the humoral response indicate a quite elevated occurrence of antibodies capable for neutralizing heterologous primary HIV-1 isolates from Rio de Janeiro. Attempts to correlate seroreactivity with HIV-1 neutralization with respect to HIV-1 polymorphism were not very successful: while the Brazilian B clade B " variant could be recognized by binding assays, no significant distinction of HIV-1 clades/variants was observed in viral neutralization assays.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFiocruz
dc.rightsopen access
dc.subjectHIV-1
dc.subjectAntibody specificity
dc.subjectNeutralization
dc.subjectGenotypes
dc.subjectFormação de Anticorpos/imunologia
dc.subjectEspecificidade de Anticorpos
dc.subjectAnticorpos Anti-HIV/imunologia
dc.subjectInfecções por HIV/imunologia
dc.subjectHIV-1/imunologia
dc.subjectBrasil
dc.subjectEstudos de Coortes
dc.subjectFeminino
dc.subjectGenótipo
dc.subjectAnticorpos Anti-HIV/genética
dc.subjectInfecções por HIV/genética
dc.subjectInfecções por HIV/transmissão
dc.subjectHumanos
dc.subjectMasculino
dc.subjectTestes de Neutralização
dc.subjectGravidez
dc.titleHIV specific humoral immune response in Rio de Janeiro, Brazil. The HEC/Fiocruz AIDS Clinical Research Group.
dc.typeArticle


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