Whole-genome sequences of influenza A(H3N2) viruses isolated from Brazilian patients with mild illness during the 2014 season

dc.creatorResende, Paola Cristina
dc.creatorMotta, Fernando Couto
dc.creatorBorn, Priscila Silva
dc.creatorMiranda, Milene
dc.creatorSiqueira, Marilda Agudo Mendonça Teixeira de
dc.date2015-11-16T16:37:22Z
dc.date2015-11-16T16:37:22Z
dc.date2015
dc.date.accessioned2023-09-27T00:08:22Z
dc.date.available2023-09-27T00:08:22Z
dc.identifierRESENDE, Paola Cristina; et al. Whole-genome sequences of influenza A(H3N2) viruses isolated from Brazilian patients with mild illness during the 2014 season. Mem Inst Oswaldo Cruz, v.110, n.1, p.148-150, Feb. 2015.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12244
dc.identifier10.1590/0074-02760140412
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897822
dc.descriptionThe influenza A(H3N2) virus has circulated worldwide for almost five decades and is the dominant subtype in most seasonal influenza epidemics, as occurred in the 2014 season in South America. In this study we evaluate five whole genome sequences of influenza A(H3N2) viruses detected in patients with mild illness collected from January March 2014. To sequence the genomes, a new generation sequencing (NGS) protocol was performed using the Ion Torrent PGM platform. In addition to analysing the common genes, haemagglutinin, neuraminidase and matrix, our work also comprised internal genes. This was the first report of a whole genome analysis with Brazilian influenza A(H3N2) samples. Considerable amino acid variability was encountered in all gene segments, demonstrating the importance of studying the internal genes. NGS of whole genomes in this study will facilitate deeper virus characterisation, contributing to the improvement of influenza strain surveillance in Brazil.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectInfluenza
dc.subjectH3N2
dc.subjectIon Torrent
dc.subjectNGS
dc.subjectVírus da Influenza A
dc.subjectVírus da Influenza A Subtipo H3N2
dc.subjectBrasil
dc.titleWhole-genome sequences of influenza A(H3N2) viruses isolated from Brazilian patients with mild illness during the 2014 season
dc.typeArticle


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