snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma

dc.creatorJorge, Natasha Andressa Nogueira
dc.creatorWajnberg, Gabriel
dc.creatorFerreira, Carlos Gil
dc.creatorCarvalho, Benilton de Sá
dc.creatorPassetti, Fabio
dc.date2018-03-01T11:23:23Z
dc.date2018-03-01T11:23:23Z
dc.date2017
dc.date.accessioned2023-09-27T00:06:41Z
dc.date.available2023-09-27T00:06:41Z
dc.identifierJORGE, Natasha Andressa Nogueira; et al. snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma. Plos One, v.12, n.8, e0183410, 8p, Aug. 2017.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25006
dc.identifier10.1371/journal.pone.0183410
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897542
dc.descriptionLung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-coding RNA that could differentiate these two groups. Here, we report two sets of differentially expressed small non-coding RNAs identified in normal and tumoral tissues of women with lung adenocarcinoma, that discriminate between smokers and non-smokers. Our findings may offer new insights on metabolic alterations caused by tobacco and may be used for early diagnosis of lung cancer.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectRNA Nucleolar Pequeno
dc.subjectRNA Interferente Pequeno
dc.subjectTabaco
dc.subjectMulheres
dc.subjectAdenocarcinoma
dc.subjectPulmão
dc.subjectlung adenocarcinoma
dc.subjectWomen
dc.subjecttobacco
dc.subjectsnoRNA
dc.subjectsnoRNA
dc.titlesnoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
dc.typeArticle


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