Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients

dc.creatorRibeiro, Camilla Rodrigues de Almeida
dc.creatorAlmeida, Nathalia Alves Araújo de
dc.creatorMartinelli, Katrini Guidolini
dc.creatorPires, Marcia Amendola
dc.creatorMello, Carlos Eduardo Brandao
dc.creatorBarros, José J.
dc.creatorPaula, Vanessa Salete de
dc.date2021-09-17T12:43:06Z
dc.date2021-09-17T12:43:06Z
dc.date2021
dc.date.accessioned2023-09-27T00:06:26Z
dc.date.available2023-09-27T00:06:26Z
dc.identifierRIBEIRO, Camilla Rodrigues de Almeida et al. Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients. Virology Journal, v. 18, n. 15, 11 p, 2021.
dc.identifier1743-422X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49101
dc.identifier10.1186/s12985-021-01487-2
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897500
dc.descriptionBackground: The hepatitis B virus (HBV) is one of the leading causes of acute, chronic and occult hepatitis (OBI) representing a serious public health threat. Cytokines are known to be important chemical mediators that regulate the diferentiation, proliferation and function of immune cells. Accumulating evidence indicate that the inadequate immune responses are responsible for HBV persistency. The aim of this study were to investigate the cytokines IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 and IL-17A in patients with OBI and verify if there is an association between the levels of these cytokines with the determination of clinical courses during HBV occult infection. Methods: 114 patients with chronic hepatitis C were investigated through serological and molecular tests, the OBI coinfected patients were subjected to the test for cytokines using the commercial human CBA kit. As controls, ten healthy donors with no history of liver disease and 10 chronic HBV monoinfected patients of similar age to OBI patients were selected. Results: Among 114 HCV patients investigated, 11 individuals had occult hepatitis B. The levels of cytokines were heterogeneous between the groups, most of the cytokines showed higher levels of production detection among OBI/HCV individuals when compared to control group and HBV monoinfected pacients. We found a high level of IL 17A in the HBV monoinfected group, high levels of TNF-α, IL-10, IL-6, IL-4 and IL-2 in OBI/HCV patients. Conclusion: These cytokines could be involved in the persistence of HBV DNA in hepatocytes triggers a constant immune response, inducing continuous liver infammation, which can accelerate liver damage and favor the develop ment of liver cirrhosis in other chronic liver diseases.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectInfecção por hepatite B oculta
dc.subjectCitocinas
dc.subjectCo-infecção do HBV/HCV
dc.subjectOccult hepatitis B infection
dc.subjectCytokines
dc.subjectHBV/HCV co-infection
dc.titleCytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
dc.typeArticle


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