Immune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature

dc.creatorLyra, Marcelo Rosandiski
dc.creatorNascimento, Maria Letícia Fernandes Oliveira
dc.creatorVaron, Andréa Gina
dc.creatorPimentel, Maria Inês Fernandes
dc.creatorAntonio, Liliane de Fátima
dc.creatorSaheki, Maurício Naoto
dc.creatorPacheco, Sandro Javier Bedoya
dc.creatorValle, Antonio Carlos Francesconi do
dc.date2015-04-08T14:50:26Z
dc.date2015-04-08T14:50:26Z
dc.date2014
dc.date.accessioned2023-09-27T00:06:05Z
dc.date.available2023-09-27T00:06:05Z
dc.identifierLYRA, Marcelo Rosandiski et al. Immune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature. Rev. Soc. Bras. Med. Trop., Uberaba, v.47, n.6, p.806-809, 2014.
dc.identifier0037-8682
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9923
dc.identifier10.1590/0037-8682-0146-2014
dc.identifier1678-9849
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897439
dc.descriptionWe report 2 cases of patients with immune reconstitution infl ammatory syndrome (IRIS) associated with cutaneous disseminated sporotrichosis and human immunodefi ciency virus (HIV) coinfection. The patients received specifi c treatment for sporotrichosis. However, after 4 and 5 weeks from the beginning of antiretroviral therapy, both patients experienced clinical exacerbation of skin lesions despite increased T CD4+ cells (T cells cluster of differentiation 4 positive) count and decreased viral load. Despite this exacerbation, subsequent mycological examination after systemic corticosteroid administration did not reveal fungal growth. Accordingly, they were diagnosed with IRIS. However, the sudden withdrawal of the corticosteroids resulted in the recurrence of IRIS symptoms. No serious adverse effects could be attributed to prednisone. We recommend corticosteroid treatment for mildto- moderate cases of IRIS in sporotrichosis and HIV coinfection with close follow-up.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedade Brasileira de Medicina Tropical
dc.rightsopen access
dc.subjectHIV
dc.subjectSporotrichosis
dc.subjectImmune Reconstitution Inflammatory Syndrome
dc.subjectIris
dc.titleImmune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature
dc.typeArticle


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