High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development

dc.creatorEspíndola, Otávio M.
dc.creatorOliveira, Luã C.
dc.creatorFerreira, Priscilla M. S.
dc.creatorLeite, Ana Claudia C. B.
dc.creatorLima, Marco Antonio S. D.
dc.creatorAndrada-Serpa, Maria José
dc.date2019-03-27T13:47:40Z
dc.date2019-03-27T13:47:40Z
dc.date2015
dc.date.accessioned2023-09-27T00:05:40Z
dc.date.available2023-09-27T00:05:40Z
dc.identifierESPÍNDOLA, Otávio M. et al. High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus Type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development. Intervirology, v. 58, p. 106-114, 2015.
dc.identifier0300-5526
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32245
dc.identifier10.1159/000371766
dc.identifier1423-0100
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897366
dc.descriptionHuman T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Therefore, we investigated parameters to discriminate HTLV-1 asymptomatic carriers (ACs) with an increased chance to develop HAM/TSP. Methods: We evaluated integration patterns of HTLV-1 provirus, the relative expression of HTLV-1 tax and HBZ mRNAs and of IFN-γ and IL-10 mRNAs, in addition to proviral load (PVL) levels. Results: HAM/TSP patients presented a higher number of large persistent HTLV-1-carrying clones compared to ACs, and the expression of the HTLV-1 tax and HBZ genes by infected cells was detected at low levels and correlated positively with PVL. In addition, HAM/TSP patients and ACs with high PVL expressed higher levels of IFN-γ mRNA in comparison to IL-10, while ACs with low PVL presented an equilibrate IFN-γ/IL-10 ratio. Conclusions: The presence of large persistent HTLV1-infected clones in association with viral gene expression, even at small levels, could stimulate the intense inflammatory response in HTLV-1-infected individuals. This was supported by a high ratio of IFN-γ/IL-10 relative expression in HAM/TSP patients and ACs with high PVL, indicating that these parameters could aid the identification of ACs with a high risk to develop HAM/TSP.
dc.description2020-03-28
dc.formatapplication/pdf
dc.languageeng
dc.publisherKarger Publishers
dc.rightsopen access
dc.subjectHuman T-cell lymphotropic virus type 1
dc.subjectHuman T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis
dc.subjectIFN-γ
dc.subjectIL-10
dc.subjectClonality
dc.subjectBiological markers
dc.titleHigh IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development
dc.typeArticle


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