Electrochemical reduction and voltammetric determination of diloxanide furoate in non-aqueous medium

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSantos, André L.
dc.creatorTakeuchi, Regina M.
dc.creatorStradiotto, Nelson Ramos
dc.date2014-05-27T11:21:36Z
dc.date2016-10-25T18:21:03Z
dc.date2014-05-27T11:21:36Z
dc.date2016-10-25T18:21:03Z
dc.date2005-09-01
dc.date.accessioned2017-04-06T01:14:27Z
dc.date.available2017-04-06T01:14:27Z
dc.identifierJournal of the Brazilian Chemical Society, v. 16, n. 5, p. 922-927, 2005.
dc.identifier0103-5053
dc.identifierhttp://hdl.handle.net/11449/68388
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68388
dc.identifier10.1590/S0103-50532005000600006
dc.identifierS0103-50532005000600006
dc.identifierWOS:000233012700006
dc.identifier2-s2.0-30744474955.pdf
dc.identifier2-s2.0-30744474955
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532005000600006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889730
dc.descriptionThe electrochemical reduction of diloxanide furoate (DF) in acetonitrile on glassy carbon electrode was studied in this work. It was observed that DF is reduced after a reversible one-electron transfer followed by an irreversible chemical reaction, diagnosed as C-Cl bond cleavage. Its reduction was followed by linear (LSV), differential pulse (DPV) and square wave voltammetry (SWV). Analytical curves were obtained for DF determination using all the investigated voltammetric techniques. For LSV was obtained a linear range (LR) from 5.0 × 10-4 to 1.0 × 10-2 mol L-1, with detection limit (DL) of 1.5 × 10-4 mol L-1 and sensitivity (S) of 2.1 × 104 μA mol-1 L. The analytical parameters obtained by DPV were: LR = 5.0 × 10-4 to 2.2 × 10-3 mol L-1, DL = 7.8 × 10-5 mol L-1, S = 3.7 × 104 μA mol-1 L. For SWV were obtained a LR = 7.5 × 10-6 to 1.2 × 10 -3 mol L-1, DL = 5.5 × 10-6 mol L -1 and S = 2.8 × 105 μA mol-1 L. Thus, the SWV was the most sensible technique, which can be used for DF determination at low concentration levels. Statistics methods were used to evaluate the analytical procedure, where recovery around to 100% was obtained for all voltammetric techniques. Relative standard deviations were lower than 5.0% (N=5). The obtained t values evaluating all the three voltammetric methods were less than the tabulated ones, indicating that there are no evidences of systematic error. ©2005 Sociedade Brasileira de Química.
dc.languageeng
dc.relationJournal of the Brazilian Chemical Society
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmoebiasis
dc.subjectDiloxanide furoate
dc.subjectVoltammetric determination
dc.titleElectrochemical reduction and voltammetric determination of diloxanide furoate in non-aqueous medium
dc.typeOtro


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