Biomarkers for susceptibility to infection and disease severity in human malaria

dc.creatorAndrade, Bruno de Bezerril
dc.creatorBarral Netto, Manoel
dc.date2014-02-25T19:42:04Z
dc.date2014-02-25T19:42:04Z
dc.date2011
dc.date.accessioned2023-09-27T00:04:56Z
dc.date.available2023-09-27T00:04:56Z
dc.identifierANDRADE, B. B.; BARRAL-NETTO, M. Biomarkers for susceptibility to infection and disease severity in human malaria. Memórias do Instituto Oswaldo Cruz, v. 106, suppl. I, p. 70-78, 2011.
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7355
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897241
dc.descriptionMalaria remains a major infectious disease that affects millions of people. Once infected with Plasmodium parasites, a host can develop a broad range of clinical presentations, which result from complex interactions between factors derived from the host, the parasite and the environment. Intense research has focused on the identification of reliable predictors for exposure, susceptibility to infection and the development of severe complications during malaria. Although most promising markers are based on the current understanding of malaria immunopathogenesis, some are also focused more broadly on mechanisms of tissue damage and inflammation. Taken together, these markers can help optimise therapeutic strategies and reduce disease burden. Here, we review the recent advances in the identification of malarial biomarkers, focusing on those related to parasite exposure and disease susceptibility. We also discuss priorities for research in biomarkers for severe malaria.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Oswaldo Cruz
dc.rightsopen access
dc.subjectMalaria
dc.subjectPlasmodium
dc.subjectBiomarker
dc.subjectInflammation
dc.subjectMarcadores Biológicos/análise
dc.subjectMalária Falciparum/transmissão
dc.subjectMalária Vivax/transmissão
dc.subjectAnimais
dc.subjectAnopheles/parasitologia
dc.subjectSuscetibilidade a Doenças
dc.subjectHumanos
dc.subjectInsetos Vetores/parasitologia
dc.subjectMalária Falciparum/genética
dc.subjectMalária Falciparum/imunologia
dc.subjectMalária Vivax/genética
dc.subjectMalária Vivax/imunologia
dc.subjectPlasmodium falciparum/imunologia
dc.subjectPlasmodium falciparum/fisiologia
dc.subjectPlasmodium vivax/imunologia
dc.subjectPlasmodium vivax/fisiologia
dc.subjectÍndice de Gravidade de Doença
dc.titleBiomarkers for susceptibility to infection and disease severity in human malaria
dc.typeArticle


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