dc.creatorMathias, Rasika Ann
dc.creatorTaub, Margaret A
dc.creatorGignoux, Christopher R
dc.creatorFu, Wenqing
dc.creatorMusharoff, Shaila
dc.creatorO'Connor, Timothy D
dc.creatorVergara, Candelaria
dc.creatorTorgerson, Dara G
dc.creatorPino-Yanes, Maria
dc.creatorShringarpure, Suyash S
dc.creatorHuang, Lili
dc.creatorRafaels, Nicholas
dc.creatorBoorgula, Meher Preethi
dc.creatorJohnston, Henry Richard
dc.creatorOrtega, Victor E
dc.creatorLevin, Albert M
dc.creatorSong, Wei
dc.creatorTorres, Raul
dc.creatorPadhukasahasram, Badri
dc.creatorEng, Celeste
dc.creatorMejia-Mejia, Delmy-Aracely
dc.creatorFerguson, Trevor
dc.creatorQin, Zhaohui S
dc.creatorScott, Alan F
dc.creatorYazdanbakhsh, Maria
dc.creatorWilson, James G
dc.creatorMarrugo, Javier
dc.creatorLange, Leslie A
dc.creatorKumar, Rajesh
dc.creatorAvila, Pedro C
dc.creatorWilliams, L Keoki
dc.creatorWatson, Harold
dc.creatorWare, Lorraine B
dc.creatorOlopade, Christopher
dc.creatorOlopade, Olufunmilayo
dc.creatorOliveira, Ricardo Riccio
dc.creatorOber, Carole
dc.creatorNicolae, Dan L
dc.creatorMeyers, Deborah
dc.creatorMayorga, Alvaro
dc.creatorKnight-Madden, Jennifer
dc.creatorHartert, Tina
dc.creatorHansel, Nadia N
dc.creatorForeman, Marilyn G
dc.creatorFord, Jean G
dc.creatorFaruque, Mezbah U
dc.creatorDunston, Georgia M
dc.creatorCaraballo, Luis
dc.creatorBurchard, Esteban G
dc.creatorBleecker, Eugene
dc.creatorAraujo, Maria Ilma Andrade Santos
dc.creatorHerrera-Paz, Edwin Francisco
dc.creatorGietzen, Kimberly
dc.creatorGrus, Wendy E
dc.creatorBamshad, Michael
dc.creatorBustamante, Carlos D
dc.creatorKenny, Eimear E
dc.creatorHernandez, Ryan D
dc.creatorBeaty, Terri H
dc.creatorRuczinski, Ingo
dc.creatorAkey, Joshua
dc.creatorBarnes, Kathleen C
dc.date2017-03-27T16:28:42Z
dc.date2017-03-27T16:28:42Z
dc.date2016
dc.date.accessioned2023-09-27T00:04:26Z
dc.date.available2023-09-27T00:04:26Z
dc.identifierMATHIAS, R. A. et al. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nature Communications, v. 7, p. 12522, 2016.
dc.identifier2041-1723
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18176
dc.identifier10.1038/ncomms12522
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897155
dc.descriptionRicardo Riccio Oliveira. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil, 1 Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA. 2 Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA. 3 Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA. 4 Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA. 5 Department of Genomic Sciences, University of Washington, Seattle, Washington 98195, USA. 6 Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. 7 Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. 8 Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. 9 Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA. 10 CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid 28029, Spain. 11 Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA. 12 Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA. 13 Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan 48202, USA. 14 Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California 94158, USA. 15 Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan 48202, USA. 16 Centro de Neumologia y Alergias, San Pedro Sula 21102, Honduras. 17 Faculty of Medicine, Centro Medico de la Familia, San Pedro Sula 21102, Honduras. 18 Tropical Medicine Research Institute, The University of the West Indies, St. Michael BB11115, Barbados. 19 Department of Parasitology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands. 20 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. 21 Instituto de Investigaciones Immunologicas, Universidad de Cartagena, Cartagena 130000, Colombia. 22 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. 23 Department of Pediatrics, Northwestern University, Chicago, Illinois 60637, USA. 24 The Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois 60637, USA. 25 Department of Medicine, Northwestern University, Chicago, Illinois 60637, USA. 26 Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202, USA. 27 Faculty of Medical Sciences Cave Hill Campus, The University of the West Indies, Bridgetown BB11000, Barbados. 28 Queen Elizabeth Hospital, The University of the West Indies, St. Michael BB11115, Barbados. 29 Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA. 30 Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA. 31 Department of Medicine and Center for Global Health, University of Chicago, Chicago, Illinois 60637, USA. 32 Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. 33 Laborato´rio de Patologia Experimental, Centro de Pesquisas Gonc¸alo Moniz, Salvador 40296-710, Brazil. 34 Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA. 35 Department of Statistics, University of Chicago, Chicago, Illinois 60637, USA. 36 Pulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA. 37 Department of Medicine, The Brooklyn Hospital Center, Brooklyn, New York 11201, USA. 38 National Human Genome Center, Howard University College of Medicine,Washington DC 20059, USA. 39 Department of Microbiology, Howard University College of Medicine,Washington DC 20059, USA. 40 Institute for Immunological Research, Universidad de Cartagena, Cartagena 130000, Colombia. 41 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, USA. 42 Immunology Service, Universidade Federal da Bahia, Salvador 401110170, Brazil. 43 Facultad de Medicina, Universidad Catolica de Honduras, San Pedro Sula 21102, Honduras. 44 Illumina, Inc., San Diego, California 92122, USA. 45 Knome Inc., Cambridge, Massachusetts 02141, USA. 46 Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA. 47 Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. 48 Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143, USA. 49 California Institute for Quantitative Biosciences, University of California, San Francisco, California 94143, USA.
dc.descriptionThe African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Publishing Group
dc.rightsopen access
dc.subjectGenética populacional
dc.subjectDiversidade genética
dc.subjectVariação genética
dc.subjectMigração humana
dc.subjectPopulação
dc.subjectMapeamento genético
dc.subjectÁfrica
dc.subjectGenetics
dc.subjectGenetic diversity
dc.subjectGenetic variation
dc.subjectHuman migration
dc.subjectPopulation
dc.subjectGenetic mapping
dc.subjectÁfrica
dc.titleA continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
dc.typeArticle


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