Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil

dc.creatorAraujo, Natalia M.
dc.creatorAraujo, Oscar C.
dc.creatorSilva, Edinete M.
dc.creatorNogueira, Cristiane A. Villela
dc.creatorNabuco, Letícia C.
dc.creatorParana, Raymundo
dc.creatorBessone, Fernando
dc.creatorGomes, Selma A.
dc.creatorTiepo, Christian
dc.creatorKay, Alan
dc.date2015-09-21T17:25:15Z
dc.date2015-09-21T17:25:15Z
dc.date2013
dc.date.accessioned2023-09-27T00:04:23Z
dc.date.available2023-09-27T00:04:23Z
dc.identifierARAUJO, Natalia M.; et al. Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil. Journal of General Virology, v. 94, p.150–158, 2013.
dc.identifier0022-1317
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11685
dc.identifier10.1099/vir.0.047324-0
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897146
dc.descriptionHepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a coinfecting HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent in both patients, with .99% of colonies hybridizing to a probe specific for this insertion. Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively. Bootscanning analysis provided evidence of recombination in several clones from both patients, with recombination breakpoints located mainly at the precore/core region. These data should encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV co-infected patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociety for General Microbiology
dc.rightsopen access
dc.subjectBrasil
dc.subjectSoropositividade
dc.subjectHepatitis B
dc.subjectGenotypes F and G
dc.subjectHuman Immunodeficiency
dc.subjectArgentina
dc.subjectBrazil
dc.subjectVirus-positive patients
dc.subjectVírus da Hepatite B
dc.subjectImunodeficiência Humana
dc.titleIdentification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil
dc.typeArticle


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