Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

dc.creatorRatcliffe, Norman A.
dc.creatorPacheco, João P. Furtado
dc.creatorDyson, Paul
dc.creatorCastro, Helena Carla
dc.creatorGonzalez, Marcelo S.
dc.creatorAzambuja, Patricia
dc.creatorMello, Cícero B.
dc.date2022-07-30T15:31:39Z
dc.date2022-07-30T15:31:39Z
dc.date2022
dc.date.accessioned2023-09-27T00:04:07Z
dc.date.available2023-09-27T00:04:07Z
dc.identifierRATCLIFFE, Norman A. et al. Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. Parasites & Vectors, v. 15, n. 112, p. 1 - 31, 2022.
dc.identifier1756-3305
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54085
dc.identifier10.1186/s13071-021-05132-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897100
dc.descriptionThis article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectParatrangênese
dc.subjectMicrobioma
dc.subjectVetores de insetos
dc.subjectMosquitos
dc.subjectTriatomíneos
dc.subjectMoscas tsé-tsé
dc.subjectFlebotomíneos
dc.subjectSegurança ambiental
dc.subjectControle de pragas
dc.subjectParatrangenesis
dc.subjectMicrobiome
dc.subjectInsect vectors
dc.subjectMosquitoes
dc.subjectTriatomines
dc.subjectTsetse flies
dc.subjectSandflies
dc.subjectEnvironmental safety
dc.subjectPest control
dc.titleOverview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
dc.typeArticle


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