Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo

dc.creatorSouza, Elen M. de
dc.creatorOliveira, Gabriel M.
dc.creatorBoykin, David W.
dc.creatorKumar, Arvind
dc.creatorHu, Qiyue
dc.creatorSoeiro, Maria Nazaré C.
dc.date2020-02-04T14:11:05Z
dc.date2020-02-04T14:11:05Z
dc.date2006
dc.date.accessioned2023-09-27T00:04:06Z
dc.date.available2023-09-27T00:04:06Z
dc.identifierSOUZA, Elen M. de et al. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. Journal of Antimicrobial Chemotherapy, v. 58, p. 610-614, July 2006.
dc.identifier0305-7453
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39710
dc.identifier10.1093/jac/dkl259
dc.identifier1460-2091
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897099
dc.descriptionAromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzi mouse model.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectDoença de Chagas
dc.subjectTerapia
dc.subjectDiamidinas aromáticas
dc.subjectCamundongos infectados
dc.subjectAromatic diamidines
dc.subjectTherapy
dc.subjectInfected mice
dc.subjectChagas Disease
dc.titleTrypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo
dc.typeArticle


Este ítem pertenece a la siguiente institución