Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAparecido Da Silva, Marcelo
dc.creatorMurino Rafacho, Bruna Paola
dc.creatorHiruma-Lima, Clelia Akiko
dc.creatorMachado Da Rocha, Lúcia Regina
dc.creatorCampaner Dos Santos, Lourdes
dc.creatorSannomiya, Miriam
dc.creatorMonteiro Souza-Brito, Alba Regina
dc.creatorVilegas, Wagner
dc.date2014-05-27T11:21:24Z
dc.date2016-10-25T18:21:00Z
dc.date2014-05-27T11:21:24Z
dc.date2016-10-25T18:21:00Z
dc.date2005-08-01
dc.date.accessioned2017-04-06T01:14:12Z
dc.date.available2017-04-06T01:14:12Z
dc.identifierChemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.
dc.identifier0009-2363
dc.identifierhttp://hdl.handle.net/11449/68357
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68357
dc.identifier10.1248/cpb.53.881
dc.identifierWOS:000231320700002
dc.identifier2-s2.0-24944567759
dc.identifier0000-0002-8645-3777
dc.identifierhttp://dx.doi.org/10.1248/cpb.53.881
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889704
dc.descriptionStrychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.
dc.languageeng
dc.relationChemical and Pharmaceutical Bulletin
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlkaloid
dc.subjectAntiulcer activity
dc.subjectStrychnos pseudoquina
dc.subjectToxic activity
dc.subjectpiroxicam
dc.subjectplant extract
dc.subjectstrychnos pseudoquina extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdrug dose regimen
dc.subjectdrug effect
dc.subjectdrug isolation
dc.subjectdrug screening
dc.subjectin vivo study
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmortality
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectplant leaf
dc.subjectstomach mucosa
dc.subjectstomach protection
dc.subjectstomach ulcer
dc.subjectstrychnos pseudoquina
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDrug Evaluation, Preclinical
dc.subjectGastric Mucosa
dc.subjectMice
dc.subjectPlant Extracts
dc.subjectPlant Leaves
dc.subjectStomach Ulcer
dc.subjectStrychnos
dc.titleEvaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice
dc.typeOtro


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