Graphene quantum dots decorated with imatinib for leukemia treatment

dc.creatorMendes, Felix Daniele
dc.creatorAlencar, Luciana Magalhães Rebelo
dc.creatorMenezes, Frederico Duarte de
dc.creatorMidlej, Victor do Valle Pereira
dc.creatorAguiar, Lorayne
dc.creatorPiperni, Sara Gemini
dc.creatorZhang, Jian
dc.creatorLiu, Yin
dc.creatorRicci-Junior, Eduardo
dc.creatorAlexis, Frank
dc.creatorAlves Junior, Severino
dc.creatorZhu, Lin
dc.creatorSantos-Oliveira, Ralph
dc.date2022-03-07T12:34:21Z
dc.date2022-03-07T12:34:21Z
dc.date2021
dc.date.accessioned2023-09-27T00:03:44Z
dc.date.available2023-09-27T00:03:44Z
dc.identifierFELIX, Daniele Mendes et al. Graphene quantum dots decorated with imatinib for leukemia treatment. Journal of Drug Delivery Science and Technology, [S. l.], v. 61, p. 1-19, 2021.
dc.identifier1773-2247
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51576
dc.identifier10.1016/j.jddst.2020.102117
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8897043
dc.descriptionThe use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nanoplatform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles’ in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.
dc.formatapplication/pdf
dc.languagepor
dc.rightsopen access
dc.subjectBiomedical device
dc.subjectDrug delivery
dc.subjectGraphene quantum dot
dc.subjectNanoparticle
dc.subjectSmart material
dc.subjectDrug delivery
dc.subjectGraphene quantum dot
dc.subjectBiomedical device
dc.subjectSmart material
dc.subjectNanoparticle
dc.titleGraphene quantum dots decorated with imatinib for leukemia treatment
dc.typePreprint


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