Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C

dc.creatorSenff, Tina
dc.creatorMenne, Christopher
dc.creatorCosmovici, Christine
dc.creatorLewis-Ximenez, Lia Laura
dc.creatorAneja, Jasneet
dc.creatorBroering, Ruth
dc.creatorKim, Arthur Y.
dc.creatorWestendorf, Astrid M.
dc.creatorDittmer, Ulf
dc.creatorScherbaum, Norbert
dc.creatorLauer, Georg M.
dc.creatorTimm, Jörg
dc.date2022-02-06T13:20:32Z
dc.date2022-02-06T13:20:32Z
dc.date2022
dc.date.accessioned2023-09-27T00:02:55Z
dc.date.available2023-09-27T00:02:55Z
dc.identifierSENFF, Tina et al. Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C. JCIinsight, v. 7, n. 2, e155432, p. 1 - 15, Jan. 2022.
dc.identifier2379-3708
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51040
dc.identifier10.1172/jci. insight.155432.
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896900
dc.descriptionInvariant NK T (iNKT) cells are implicated in viral clearance; however, their role in hepatitis C virus (HCV) infection remains controversial. Here, iNKT cells were studied during different stages of HCV infection. iNKT cells from patients with acute HCV infection and people who inject drugs (PWID) with chronic or spontaneously resolved HCV infection were characterized by flow cytometry. In a longitudinal analysis during acute HCV infection, frequencies of activated CD38+ iNKT cells reproducibly declined in spontaneously resolving patients, whereas they were persistently elevated in patients progressing to chronic infection. During the first year of infection, the frequency of activated CD38+ or CD69+ iNKT cells strongly correlated with alanine transaminase levels with particularly pronounced correlations in spontaneously resolving patients. Increased frequencies of activated iNKT cells in chronic HCV infection were confirmed in cross-sectional analyses of PWID with chronic or spontaneously resolved HCV infection; however, no apparent functional differences were observed with various stimulation protocols. Our data suggest that iNKT cells are activated during acute hepatitis C and that activation is sustained in chronic infection. The correlation between the frequency of activated iNKT cells and alanine transaminase may point toward a role of iNKT cells in liver damage.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInsight
dc.rightsopen access
dc.subjectHepatite C
dc.subjectAtivação de células iNKT
dc.subjectSangue periférico
dc.subjectDano hepático
dc.subjectPeripheral blood
dc.subjectiNKT cell activation
dc.subjectCorrelate
dc.subjectLiver damage
dc.subjectAcute hepatitis C
dc.titlePeripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
dc.typeArticle


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