Autoimmune Hepatitis and Autoimmune Hepatitis Overlap With Sclerosing Cholangitis: Immunophenotype Markers in Children and Adolescents

dc.creatorLiu, Priscila Menezes Ferri
dc.creatorSilva, Ana Cristina Simões e
dc.creatorTorres, Karen Cecília de Lima
dc.creatorCampos, Silva Soraya Luiza
dc.creatorAquino, Diego Júnior Queiroga de
dc.creatorFerreira, Maria Luisa Marques
dc.creatorFagundes, Eleonora Druve Tavares
dc.creatorMiranda, Débora Marques de
dc.creatorFerreira, Alexandre Rodrigues
dc.date2018-09-13T18:20:38Z
dc.date2018-09-13T18:20:38Z
dc.date2018
dc.date.accessioned2023-09-27T00:02:41Z
dc.date.available2023-09-27T00:02:41Z
dc.identifierLIU, Priscila Menezes Ferri et al. Autoimmune Hepatitis and Autoimmune Hepatitis Overlap With Sclerosing Cholangitis: Immunophenotype Markers in Children and Adolescents. Journal of Pediatric Gastroenterology and Nutrition, v. 66, n. 2, p. 204-211, 2018.
dc.identifier0277-2116
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28765
dc.identifier10.1097/MPG.0000000000001783
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896860
dc.descriptionOBJECTIVE: The pathophysiology of autoimmune hepatitis (AIH) may involve the activation of immune cells and changes in the expression of cellular markers. The aim of the present study was to characterize the immunophenotype markers of lymphocytes and monocytes in the peripheral blood of children and adolescents with type 1 AIH and AIH overlap with sclerosing cholangitis (overlap syndrome [OS]). METHODS: This is a cross-sectional study of 20 children and adolescents diagnosed with type 1 AIH and 19 with OS. Fifteen healthy subjects were included as controls. Flow cytometric analysis was used to identify markers of inflammation and autoimmunity. RESULTS: The total number of CD4 T cells was higher in the AIH patients compared with the controls. The number of CD4 T cells expressing CCR3 and CD28 was higher in the AIH group than in the control group. CD45RO was more highly expressed in the AIH group, whereas CD45RA was more highly expressed in the OS group. In regard to CD8 T lymphocytes, the CCR3 expression was higher in both groups of patients. Patients with OS had the highest expression of CD45RA and CD25. In monocytes, human leukocyte antigen DR (HLA-DR) was less expressed in both groups of patients. CONCLUSIONS: Complex phenotype features may be involved in the pathophysiology of AIH, accounting for changes in immune system regulation mechanisms. In conclusion, even after good response to treatment, patients still have immune activity signals at the cellular level.
dc.description2100-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsrestricted access
dc.subjectDoenças autoimunes
dc.subjectHepatite autoimune
dc.subjectCrianças
dc.subjectImunofenótipo
dc.subjectAutoimmune disease
dc.subjectAutoimmune hepatitis
dc.subjectChildren
dc.subjectImmunophenotype
dc.titleAutoimmune Hepatitis and Autoimmune Hepatitis Overlap With Sclerosing Cholangitis: Immunophenotype Markers in Children and Adolescents
dc.typeArticle


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