Developing vaccines to combat hookworm infection and intestinal schistosomiasis

dc.creatorHotez, Peter J.
dc.creatorBethony, Jeffrey Michael
dc.creatorDiemert, David J.
dc.creatorPearson, Mark S.
dc.creatorLoukas, Alex
dc.date2013-09-16T17:50:26Z
dc.date2013-09-16T17:50:26Z
dc.date2010
dc.date.accessioned2023-09-27T00:01:21Z
dc.date.available2023-09-27T00:01:21Z
dc.identifierHOTEZ, Peter J. et al. Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Nat Rev Microbiol., v. 8, p. 814-826, 2010.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6896
dc.identifier10.1038/nrmicro2438
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896626
dc.descriptionHookworm infection and schistosomiasis rank among the most important health problems in developing countries. Both cause anaemia and malnutrition, and schistosomiasis also results in substantial intestinal, liver and genitourinary pathology. In sub-Saharan Africa and Brazil, co-infections with the hookworm, Necator americanus, and the intestinal schistosome, Schistosoma mansoni, are common. The development of vaccines for these infections could substantially reduce the global disability associated with these helminthiases. New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature
dc.rightsrestricted access
dc.subjectSchistosomiasis
dc.subjectvaccines
dc.titleDeveloping vaccines to combat hookworm infection and intestinal schistosomiasis
dc.typeArticle


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